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Taufiq-Yap, Y.H
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Medicine & Pharmacology

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EFFECTS OF STROBILANTHES CRISPUS EXTRACT ON THE APOPTOTIC PATHWAY OF HUMAN LIVER CARCINOMA CELL LINES Endrini, Susi; Suherman, Suherman; Rahmat, Asmah; Ismail, Patimah; Taufiq-Yap, Y.H; Othman, Fauziah
Jurnal Kedokteran YARSI Vol 15, No 1 (2007): JANUARI - APRIL 2007
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.011 KB) | DOI: 10.33476/jky.v15i1.998

Abstract

Previous study has been shown the potential anticarcinogenic effect of Strobilanthes crispus, a plant native to countries from Madagascar to Indonesia, on human liver cancer (HepG-2) cell lines. The objective of the present study was to investigate the mechanism of anticarcinogenic effectof S.crispus extract through apoptotic pathway. Exposure of HepG-2 cells to S.crispus extract resulted in induction of apoptosis in a dose-dependent manner as measured by Fluoresence Microscopy and Confocal Laser Scanning Microscopy analysis. These findings provide important new insight into the possible molecular mechanisms of the anticancer activity of S.crispus.
Co-Authors Asmah Rahmat Fauziah Othman Patimah Ismail Susi Endrini Syamsul Arifin