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All Journal Majalah Patologi Indonesia JIB : Journal Islamic Banking
Diana Purnamasari
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Economics, Econometrics & Finance Health Professions Public Health

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Ekspresi p16 dan CDK4 pada Berbagai Stadium T Karsinoma Laring Diana Purnamasari; Dyah Fauziah
Majalah Patologi Indonesia Vol 29 No 1 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.885 KB) | DOI: 10.55816/mpi.v29i1.404

Abstract

BackgroundDefect in cell cycle control affect cell proliferation and play an important role in pathogenesis of cancer. Recently, some proteins areknown to have an influence in cell cycle proliferation. P16 and CDK4 may have influenced in laryngeal carcinoma. CDK4, anoncogene, can form cyclin D1-CDK4 complex that inactivates pRb so that the cell cycle goes from G1 phase to S phase. P16, atumor suppressor protein, can prevent cyclin D1-CDK4 complex so that inhibit cell proliferation.MethodsThis research was an observational analysis study with paraffin block samples, consists of 3 samples of stage T1 and each 10samples of stage T2, T3 and T4 in Laboratory of Anatomical Pathology of RSUD dr. Soetomo that was collected from 2013-2015.Samples were stained with antibody of p16 and CDK4. P16 and CDK4 expression were assessed based on the percentage andintensity of tumor cells that were stained. The differences between variables were analyzed by Kruskal-Wallis. The correlationbetween variables was analyzed by Spearman correlation test.ResultsP16 expression of carcinoma larynx T1 (88.33±7.64), T2 (85.00±5.27), T3 (61.00±21.83), and T4 (62.00±25.30). Besides CDK4expression of carcinoma larynx T1 (43.33±15.28), T2 (47.00±14.18), T3 (75.00±8.50), and T4 (70.00±9.43). Statistic analysisshowed significant differences between p16 and CDK4 expression on each stade of carcinoma larynx (p=0.017 and p=0.000). Andthere were corelation between p16 and CDK4 expression on each stage of carcinoma larynx (p=0.000 and p=0.000).ConclusionThe lower p16 expression and the higher CDK4 expression showed the higher stage of carcinoma larynx.
The Influence Of Financial Innovation And Financial Ratio On The Financial Performance Of The Banking Sector Diana Purnamasari
Jurnal Perbankan Syariah Vol 4 No 1 (2024): JUNI
Publisher : Program Studi Perbankan Syariah, Fakultas Ekonomi dan Bisnis Islam, Institut Agama Islam Nahdlatul Ulama Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51675/jib.v4i1.826

Abstract

Financial performance involves analyzing how well a company adheres to financial regulations and standards. This study investigates the impact of financial innovation and financial ratios on the performance of banking companies from 2009 to 2018. The research employs a descriptive approach with quantitative methods, utilizing secondary data. Purposive sampling is the chosen sampling method. Data analysis is conducted using panel regression analysis techniques, which include the Chow test, Hausman test, Lagrange multiplier test, classical assumption test, and partial regression test. The findings indicate that the NPL ratio has a significant negative effect on ROA, the LDR ratio has a significant positive effect on ROA, while the financial innovation variable and CAR had no effect on ROA
Peran Permodalan dalam Meningkatkan Efisiensi Biaya melalui Pengaruh Suku Bunga dan Inflasi di Sektor Perbankan Diana Purnamasari; Muslim, Dzurotun Khanifah; Wardah Sukriya
Jurnal Perbankan Syariah Vol 5 No 1 (2025): JUNI
Publisher : Program Studi Perbankan Syariah, Fakultas Ekonomi dan Bisnis Islam, Institut Agama Islam Nahdlatul Ulama Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51675/jib.v5i1.1119

Abstract

Banks are financial intermediary institutions, therefore in a country a bank is needed that can carry out its functions properly and operate optimally. This study aims to determine the effect of capital, interest rates and inflation on bank cost efficiency in banks going public in 2021-2024. The data used is secondary data obtained through the idx.co.id website. The data analysis method used is multiple linear regression. The results of this study indicate that simultaneously capital, interest rates, and inflation have a significant effect on cost efficiency, partially capital and interest rates have a negative and insignificant effect on cost efficiency, partially inflation has an insignificant effect on cost efficiency. The greater the capital owned by a bank, the greater the size of the bank. Large bank capital can be channeled to third parties in the form of financing, or other investments that provide profits for the bank. if the bank's profits are large, then the bank's cost efficiency will also increase.
Ekspresi p16 dan CDK4 pada Berbagai Stadium T Karsinoma Laring Diana Purnamasari; Dyah Fauziah
Majalah Patologi Indonesia Vol. 29 No. 1 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i1.404

Abstract

BackgroundDefect in cell cycle control affect cell proliferation and play an important role in pathogenesis of cancer. Recently, some proteins areknown to have an influence in cell cycle proliferation. P16 and CDK4 may have influenced in laryngeal carcinoma. CDK4, anoncogene, can form cyclin D1-CDK4 complex that inactivates pRb so that the cell cycle goes from G1 phase to S phase. P16, atumor suppressor protein, can prevent cyclin D1-CDK4 complex so that inhibit cell proliferation.MethodsThis research was an observational analysis study with paraffin block samples, consists of 3 samples of stage T1 and each 10samples of stage T2, T3 and T4 in Laboratory of Anatomical Pathology of RSUD dr. Soetomo that was collected from 2013-2015.Samples were stained with antibody of p16 and CDK4. P16 and CDK4 expression were assessed based on the percentage andintensity of tumor cells that were stained. The differences between variables were analyzed by Kruskal-Wallis. The correlationbetween variables was analyzed by Spearman correlation test.ResultsP16 expression of carcinoma larynx T1 (88.33±7.64), T2 (85.00±5.27), T3 (61.00±21.83), and T4 (62.00±25.30). Besides CDK4expression of carcinoma larynx T1 (43.33±15.28), T2 (47.00±14.18), T3 (75.00±8.50), and T4 (70.00±9.43). Statistic analysisshowed significant differences between p16 and CDK4 expression on each stade of carcinoma larynx (p=0.017 and p=0.000). Andthere were corelation between p16 and CDK4 expression on each stage of carcinoma larynx (p=0.000 and p=0.000).ConclusionThe lower p16 expression and the higher CDK4 expression showed the higher stage of carcinoma larynx.
Co-Authors DYAH FAUZIAH, DYAH Muslim, Dzurotun Khanifah Wardah Sukriya