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Combination Therapy in Melasma with Lentigo Solaris: Case Report Lumbantoruan, Erty Witalaya; Nasution, Khairina; Nelva Karmila Jusuf
Sumatera Medical Journal Vol. 3 No. 1 (2020): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v3i1.690

Abstract

Background: Melasma and lentigo solaris are common, recurrent, and refractory acquired hyperpigmentation disorder. In spite of variety of therapeutic options available for this cosmetically disfiguring condition, the treatment of this condition remains a challenge. Azelaic acid (AA) is a depigmenting agent which acts by inhibition of DNA synthesis and mitochondrial enzymes, thereby inducing direct cytotoxic effects on melanocytes. Glycolic acid (GA) peel is one of the most versatile agents in the treatment of melasma and lentigo solaris. GA peels alone or in combination with topical hypopigmenting agents has shown encouraging results. However, there is paucity of controlled trial demonstrating the efficacy of GA peels in conjunction with topical AA. Case: A 42-years-old female, works as a street vendor, came with dark brown spots on both cheeks, nose, chin and forehead that spreads to whole face since one year ago. She had a history of using contraceptives. From the dermatological examination, there were multiple well-circumscribed, irregular hyperpigmented macules that asymmetrical, with size ranging from lenticular to plaque on the maxillary, left buccalis, mentalis and frontalis region. We also found a numular dark brown hyperpigmented macules on right zygoma. She was diagnosed with melasma and lentigo solaris. The Melasma Area Severity Index (MASI) score was 25.6, which classified as moderate melasma. She was treated with 20% azaleic acid cream twice a day, broadspectrum sunscreen with SPF 50 and GA 20% peeling. Result: After 6 weeks of treatment, there were significant improvement in both melasma and lentigo solaris.
PERKEMBANGAN TERKINI PATOGENESIS DAN TATALAKSANA SELULIT Ira Armayanti; Nelva Karmila Jusuf
Media Dermato-Venereologica Indonesiana Vol 49 No 4 (2022)
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v49i4.388

Abstract

Cellulite is characterized by skin topography alterations that have been described as peau d'orange, cottage cheese or mattress-like appearance. All age groups and both sexes could have cellulite, especially post-puberty females. Cellulite is more common seen in Caucasian than Asian woman. Based on the study of woman skin anatomy, fat cells and connective tissue are aligned vertically so that fat cells could protrude into the skin layer and cause cellulite. The pathogenesis of cellulite is controversial and the etiology are multifactorial. If the etiopathogenesis are already known, more effective treatments could be developed. Three main cellulite theories are adipocyte accumulation, water retention and septa fibrosis. Several combination theories associated with cellulit include genetic, hormonal, vascular insufficiency, chronic inflammation, dietary and neurological effects. Clinical evaluation and associated conditions are important for assessing the severity of cellulite and are useful for determining various treatment options. To date, cellulite treatment still a challenge, require long-term stability of influencing factors.
PENGGUNAAN FILLER DAN SKIN BOOSTER PADA PEREMAJAAN KULIT: Penggunaan Filler pada Peremajaan kulit Sri Karunia Setio Wati; Nelva Karmila Jusuf
Media Dermato-Venereologica Indonesiana Vol 51 No 2 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i2.447

Abstract

Filler adalah produk yang disuntikkan melalui jarum tajam atau kanula ke dalam kulit pada kedalaman yang berbeda, untuk memberikan volume pada dermis dan lemak subkutan. Filler banyak digunakan untuk indikasi estetika, karena dapat memperbaiki penampilan dengan menghaluskan atau menyamarkan garis-garis, tanda penuaan, dan kerutan di wajah dan tubuh. Selain itu, terdapat partikel kecil asam hialuronat (HA) yang dikenal sebagai skinbooster, yang merupakan metode baru dalam peremajaan kulit. Penyuntikan skinbooster berbeda dari filler, dimana penyuntikan dilakukan secara serial micropuncture intradermal dengan sejumlah kecil produk yang tidak memiliki fungsi untuk menciptakan volume (efek "volumizing") tetapi untuk melembabkan, mengencangkan dan menutrisi kulit secara mendalam dan tahan lama untuk melawan efek penuaan kulit. Tindakan filler dan skinbooster ini dapat dilakukan sesuai indikasi, dengan tetap memperhatikan kontraindikasinya. Selain itu juga harus dilakukan sesuai dengan prosedur yang direkomendasikan, untuk mengurangi kemungkinan terjadinya komplikasi.