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Adikurniawan, Yuko Mulyono
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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EFEKTIVITAS PATCH SEDERHANA DARI EKSTRAK DAUN KAYU JAWA (Lannea coromandelica (Houtt.) Merr.) TERHADAP PENYEMBUHAN LUKA SAYAT PADA TIKUS (Rattus norvegicus) Azzahrah, Nur Faatimah; Jamaluddin, Abdul Wahid; Adikurniawan, Yuko Mulyono
Jurnal Ilmiah As-Syifaa Vol 11, No 2 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (428.381 KB) | DOI: 10.33096/jifa.v11i2.531

Abstract

Kayu jawa plants are one type of traditional plant that is often used to treat wounds, both internal and external wounds. This plant has been shown to have anti-microbial, anti-oxidant and anti-inflammatory effects. Flavonoid compounds have anti-inflammatory activity by protecting erythrocyte membranes against membrane damage causing hemolysis because flavonoids can inhibit inflammatory mediators and free radicals. This study aims to determine the effect of the administration of simple patch from Kayu Jawa leaves extract (Lannea coromandelica Houtt. (Merr.)) On wound healing in white rats (Rattus norvegicus) by looking at the extent of the wound closure and changes in wound morphology compared to controls. This study used a laboratory experimental method with 25 rats as test animals divided into 5 treatment groups, namely 3 treatment groups (simple patch from 2.5% kayu jawa leaves extract, simple patch from 5% kayu jawa leaves extract, and simple patch from 10% kayu jawa leaves extract), 1 positive control group (simple patch from povidone iodine) and 1 negative control group (simple patch without kayu jawa leaves extract). The conclusions of the study was the administration of 5% Kayu Jawa leaves extract gave the best effect in accelerating wound healing.
UJI AKTIVITAS JUS BUAH JAMBU BIJI BERDAGING MERAH (Psidium guajava L.) TERHADAP PENINGKATAN TROMBOSIT PADA MENCIT (Mus musculus L.) YANG DIINDUKSI KLORAMFENIKOL Hosea, Cindy Trie Permatasari; Jamaluddin, Abdul Wahid; Adikurniawan, Yuko Mulyono
Jurnal Ilmiah As-Syifaa Vol 10, No 2 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.496 KB) | DOI: 10.33096/jifa.v10i2.340

Abstract

Thrombocytopenia is the most common hemostatic disorder acquired in dogs and can be a life-threatening. Guava fruit and leaves extract are believed to improve thrombocyte counts. The purpose of this study was to prove that administration of guava juice could improve  thrombocyte count in mice that have thrombocytopenia after induced by chloramphenicol. We were used 24 mice as samples divided into 4 groups : KS group (given aquades for 12 days), KN group (induced by chloramphenicol for 7 days, then aquades on next 5 days), group P1 (induced by chloramphenicol for 7 days then guava juice 5 g/ml concentration on 5 next day); and group P2 (induced by chloramphenicol for 7 days then guava juice 10 g/ml concentration on the next 5 days). Thrombocyte count was measured three times, before treatment (day 0), after chloramphenicol induction (day 7), and after guava juice (day 12). Data of thrombocyte count was analyzed using one way Anova and Post Hoc LSD test. The results showed that the guava juice (Psidium guajava L.) concentration of 5 g/ml and 10 g/ml had significant effect (p <0,05) to increase platelet numbers  in mice after induced by chlorampenicol dose 30mg/30grBW.
Co-Authors Abdul Wahid Jamaluddin Azzahrah, Nur Faatimah Hosea, Cindy Trie Permatasari