Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Media Farmasi Indonesia Indonesian Journal of Jamu
Agustina, Ruth Ditya
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Other

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Uji Aktivitas Penangkapan Radikal DPPH (1,1-Diphenyl-2-Picrylhdrazyl) Ekstrak Etanol Kayu Secang (Caesalpinia sappan L.) Tanzaq, Tan Tanando; Agustina, Ruth Ditya; Setiawati, Kemala Endar; Cahyani, Intan Marta
Media Farmasi Indonesia Vol. 14 No. 1 (2019): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (433.648 KB)

Abstract

Antioksidan merupakan senyawa yang dapat mencegah terbentuknya radikal bebas serta menghambat reaksi oksidasi dengan mengikat radikal bebas dan molekul lainnya yang bersifat reaktif. Kayu secang (Caesalpinia sappan L.) mengandung flavonoid dan alkaloid yang dapat berpotensi sebagai antioksidan. Senyawa flavonoid memiliki potensi sebagai antioksidan karena memiliki gugus hidroksil yang terikat pada karbon cincin aromatik sehigga dapat menangkap radikal bebas yang dihasilkan dari reaksi peroksidasi lemak. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak etanol dari kayu secang yang ditunjukkan dengan nilai IC50 dan memiliki nilai persentase daya hambat pada konsentrasi 50 µg/mL, 100 µg/mL, 150 µg/mL, 200 µg/mL, 250 µg/mL.. Kayu secang diekstraksi menggunakan metode maserasi dengan pelarut etanol 96%.Hasil uji aktivitas antioksidan ekstrak etanol kayu secang secara kualitatif menunjukkan bahwa sampel postif mengandung antioksidan dan uji secara kuantitatif menunjukkan hasil nilai IC50 yaitu 74,4395 µg/mL yang tergolong dalam kategori antioksidan kuat.
Formulation and Characterization of Peel-Off Gel Mask Containing Secang (Caesalpinia sappan L.) Wood Extract with Strong Antioxidant Activity Cahyani, Intan Martha; Tanzaq, Tan Tanando; Agustina, Ruth Ditya; Setiawati, Kemala Endar
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.403

Abstract

Secang (Caesalpinia sappan L.) wood contains flavonoid compounds such as brazilin, 3'-O-methylbrazilin, sappanin chalcone, and sappan chalcone, which act as primary and secondary antioxidants. Antioxidants are substances that can inhibit oxidation reactions by neutralizing free radicals. Enhancing the antioxidant potential of C. sappan wood can be achieved by developing a topical dosage form. Peel-off gel masks are an ideal form due to their ability to improve skin health and provide ease and comfort in application. This study aimed to formulate a peel-off gel mask containing C. sappan extract and evaluate its physical properties and antioxidant activity. The formulations were prepared using 2.5%, 5%, and 7.5% extract with sodium carboxymethyl cellulose, polyvinyl alcohol, and propylene glycol as the base. The resulting masks were assessed for physical characteristics (pH, viscosity, spreadability, adhesiveness, and drying time) and antioxidant activity using the DPPH method. The results indicated that increasing the extract concentration significantly (p < 0.05) increased viscosity, adhesiveness, and drying time, while decreasing pH, spreadability, and IC₅₀ value. All formulations demonstrated strong antioxidant activity (IC₅₀ between 50–100 µg/mL), with IC₅₀ values of 88.71 µg/mL, 81.58 µg/mL, and 79.04 µg/mL, respectively.
Co-Authors Cahyani, Intan Marta Intan Martha Cahyani, Intan Martha Setiawati, Kemala Endar Tanzaq, Tan Tanando