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All Journal E-Jurnal Medika Udayana Jurnal Penyakit Dalam Indonesia
Rai, Ida Bagus Ngurah
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Health Professions Medicine & Pharmacology

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Association between Silica Dust Exposure and Serum Transforming Growth Factor-β1 in Stone Quarry Workers Wijaya, I Putu Eka Krisnha; Rai, Ida Bagus Ngurah; Andrika, I Putu
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
Publisher : UI Scholars Hub

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Abstract

Introduction. Silicosis is a disease that most often occurred as a result of silica dust exposure. Silica dust particles will stimulate alveolar macrophages to secrete proinflammatory mediators for fibroblast proliferation and collagen deposition. TGF-ß1 is one of the most extensively involved mediators in the development of fibrosis. To date, several studies have not shown consistent results regarding the association between silica dust exposure and TGF-β1. This study examined silica dust exposure and serum TGF-β1, which aims to determine the risk of silicosis in stone quarry workers. Methods. An analytic cross-sectional study was conducted at Company X, Karangasem in March 2016. The studied variables were silica dust exposure using nephelometer dust monitoring, serum TGF-β1 using ELISA method, nutritional status from weight scales, with age, smoking, and use of personal protective equipment (PPE) from an interview. Spearman correlation test is used to determine the correlation between silica dust exposure with serum TGF-β1. Multivariate linear regression analysis was used to asses the effect of silica dust exposure, age, nutritional status, cigarette smoking, and use of PPE with TGF-β1 serum. Results. There were 55 samples of stone quarry workers in this study. From the Spearman correlation test, there was a significant correlation between silica dust exposure with serum TGF-β1¬, (r) = 0.319, p = 0.018. In multivariate regression analyzes test, there were significant associations between silica dust exposure and nutritional status with serum TGF-β1, p = 0.042 and p = 0.012. Conclusions. There was an association between silica dust exposure and increasing serum TGF-β1 of stone quarry workers.
KEAMANAN DAN EFEKTIVITAS E-CIGARETTE SEBAGAI ALTERNATIF ROKOK KONVENSIONAL TERHADAP PARU BERDASARKAN PERBANDINGAN TES SPIROMETRI: A SYSTEMATIC REVIEW Elkurnia, Raymond Timothy; Rai, Ida Bagus Ngurah; Candrawati, Ni Wayan; Sajinadiyasa, I Gede Ketut
E-Jurnal Medika Udayana Vol 11 No 8 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i8.P11

Abstract

E-cigarette kerap dijadikan alternatif bagi orang yang ingin berhenti merokok, namun e-cigarette tidak dapat dipastikan kemananan serta efektivitasnya. Systematic review ini dibuat dengan tujuan untuk mengetahui keamanan penggunaan e-cigarette dibandingkan dengan rokok konvensional terhadap fungsi paru, serta efektivitas penggunaanya. Pencarian studi dengan karakteristik randomized controlled trial/RCT dilakukan sesuai dengan kaidah PRISMA dengan menggunakan kata kunci‘ electronic nicotine delivery system’, ‘e-cigarette’, ‘e-cig’, ‘lung function’, ‘spirometry’, ‘FEV1/FVC’. Dari 110 studi, didapatkan 5 studi RCT yang memiliki hasil yang bervariasi.
Co-Authors Andrika, I Putu Candrawati, Ni Wayan Dyah Pradnyaparmita Duarsa Elkurnia, Raymond Timothy I Gede Ketut Sajinadiyasa I Nyoman Mangku Karmaya I Wayan Gede Artawan Eka Putra, I Wayan Gede Artawan Eka Karminiasih, Ni Luh Putu Wijaya, I Putu Eka Krisnha