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All Journal Journal of Applied Pharmaceutical Research Caraka Tani: Journal of Sustainable Agriculture
Adekunle, Adedotun Adeyinka
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Agriculture, Biological Sciences & Forestry Medicine & Pharmacology

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Mycotic loads’ determination of non-sterile pharmaceuticals in Lagos state and 16S RDNA identification of the fungal isolates Oyebanji, Elizabeth Olawumi; Adekunle, Adedotun Adeyinka; Coker, Herbert Alexander B.; Adebami, Gboyega Ebenezer
Journal of Applied Pharmaceutical Research Vol. 6 No. 2 (2018)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1167.612 KB) | DOI: 10.18231/2348-0335.2018.0007

Abstract

Pharmaceuticals are medicinal products used in the prevention, treatment, and diagnosis of diseases. As such, the presence of microorganisms’ especially fungal toxins can reduce or eliminate the product's therapeutic activity and constitute a potential danger to patient health. This study attempts to determine the fungal loads of liquid preparation used as medication in Lagos State and its environs and identify the fungal isolates. 252 different types of oral liquid drugs (200syrups and 52 suspensions) which included paracetamol syrup, cough syrup and antibiotics suspension manufactured in five different pharmaceutical industries in Nigeria were methodically sampled and analyzed for fungi contamination using standardized method. The isolated fungi were identified using morphological characterization as well as 16SrDNA sequencing. 13% of the sampled syrups were found to be contaminated with fungi where thecolony forming units for paracetamol syrup, cough syrup and antibiotics suspension ranges from 2.0x101 - 9.6×104; 1.0x102- 7.5x104 and 1.0x101- 8.8×104cfu/ml respectively while87% yielded no growth.Thirteen (13) morphologically different species of fungi were identified which included Aspergillus niger strains, A. tamari strains, A. japonicas, A. flavus, A. awamari, A. ellipticus, A. tubingensis, Meyerozyma aaribbica, Candida carpophila and Eurotiomycetes spp, The presence of microorganisms in oral liquid samples might explain the treatment complicacy of the diseased children. Therefore, microbiological quality of such drugs is thus suggested.
Influence of Leaf Extract of Lantana camara Integrated with Maize-based Coating on the Quality of Fresh Talinum triangulare and Telfairia occidentalis Leaves Adeogun, Oluwagbenga Oluwasola; Ebabhi, Abosede Margaret; Adongbede, Erute Magdalene; Oluwa, Omoteso Karfeel; Adekunle, Adedotun Adeyinka
Caraka Tani: Journal of Sustainable Agriculture Vol 38, No 1 (2023): April
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/carakatani.v38i1.57446

Abstract

Fresh Talinum triangulare and Telfairia occidentalis leaves have a short shelf life; therefore, there is a need to enhance their shelf life using natural antimicrobials to maintain their freshness. The effect of an ethanolic extract of Lantana camara leaf (10% w/v) integrated with a maize-based edible coating on fresh T. triangulare and T. occidentalis leaves was studied. Fresh T. triangulare and T. occidentalis leaves were evaluated for quality (pH, total carotenoid content, ascorbic acid, total phenolic content, fungal load, antioxidant activity, total soluble solids and browning potential) using a centered second-order polynomial (quadratic) model over a 9-day period. The pH values, browning potential, total soluble solids, and fungal loads of T. triangulare and T. occidentalis treated with the ethanolic leaf extract of L. camara integrated with maize-based coating had higher values than those of T. triangulare and T. occidentalis without treatment. Meanwhile, the total carotenoid content, ascorbic acid, total phenolic acid, and total antioxidant capacity of T. triangulare and T. occidentalis treated with the ethanolic leaf extract of L. camara integrated with maize-based coating had reduced values compared to T. triangulare and T. occidentalis without treatment. The disparity in the quality parameter values indicates bioactivity in L. camara integrated with a maize-based coating. This study shows that the integration of the ethanolic extract of the leaf of L. camara with the maize-based coating could be used as a biopreservation agent to improve the shelf life of T. triangulare and T. occidentalis.
Co-Authors Adebami, Gboyega Ebenezer Adeogun, Oluwagbenga Oluwasola Adongbede, Erute Magdalene Coker, Herbert Alexander B. Ebabhi, Abosede Margaret Oluwa, Omoteso Karfeel Oyebanji, Elizabeth Olawumi