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All Journal Jurnal Ilmiah Cendekia Eksakta Sinteza Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Devi, Sisca
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology

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PERBANDINGAN GUAR GUM DAN HIDROKSIPROPIL METIL SELULOSA SEBAGAI GELLING AGENT TERHADAP KARAKTERISTIK FISIK SEDIAAN MASKER PEEL OFF EKSTRAK DAUN SALAM (Syzygium polyanthum) Devi, Sisca; Widiyana, Widiyana
CENDEKIA EKSAKTA Vol. 7 No. 1 (2022)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v7i1.6548

Abstract

Radikal bebas bersifat reaktif dan tidak stabil sehingga dapat menyebabkan penuaan dini. Radikal bebas dapat diatasi dengan senyawa antioksidan. Daun salam (Syzyum polyanthum) mengandung senyawa flavonoid yang bermanfaat sebagai antioksidan. Sediaan kosmetik yang cocok untuk penghantaran efek antioksidan adalah masker peel off. Salah satu bahan dalam formulasi masker peel off adalah gelling agent. Penelitian ini bertujuan untuk mengetahui perbedaan karakteristik fisik gelling agent guar gum dan hidroksipropil metil selulosa pada sediaan masker peel off ekstrak daun salam. Penelitian ini merupakan penelitian eksperimental menggunakan 2 jenis gelling agent yang berbeda pada 2 formula yaitu semi sintetik (HPMC K100M) dan gom alam (guar gum). Formula masker peel off dievaluasi karakteristik fisik meliputi organoleptis, pH sediaan, homogenitas, daya lekat, daya sebar, waktu mengering, dan viskositas. Hasil pengujian dianalisis dengan membandingkan hasil karakteristik fisik masing-masing formula menggunakan uji t dan uji Mann Whitney dengan taraf kepercayaan 95%. Hasil uji karakteristik fisik masker peel off ekstrak daun salam menunjukkan terdapat perbedaan bermaknapada  uji daya lekat dan waktu mengering.Kata kunci: ekstrak daun salam (nama latin), guar gum, hidroksi metil selulosa, masker peel off
Perbedaan Kombinasi Konsentrasi Bahan Pengikat Pati Garut (Maranta Arundinaceae. L) Dan Pati Talas (Colocasia Esculanta L. Scoot) Terhadap Karakteristik Fisik Sediaan Tablet Hisap Ekstrak Jahe Merah (Zingiber Officinale Var. Rubrum) Devi, Sisca; Baiti, Hilma Nur
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 2 (2024): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i2.5290

Abstract

Red ginger contains gingerol which is used as a throat lozenge. One of the dosage forms used in developing the use of red ginger is lozenges. Making lozenges requires additional ingredients in the form of a binder which can be obtained from starch. Arrowroot starch and taro starch contain amylose and amylopectin which have the ability to adhere. The combination of the use of arrowroot starch and taro starch binders has an impact on the characteristics of the lozenges produced. This research aims to determine the differences in the combination of using concentrations of binding agents, namely arrowroot starch and taro starch, on the physical characteristics of red ginger extract lozenges.This research is an experimental study with the independent variable being the combination of concentrations of arrowroot starch and taro starch (100:0); (50:50); (0:100). Testing of the physical characteristics of red ginger extract lozenges included organoleptic and tablet dimensions, weight uniformity, tablet hardness and friability and disintegration time. Analysis of normally distributed and homogeneous data using One-Way Anova at a confidence level of 95% followed by Post Hoc testing. The Kruskal-Wallis test is used for data that is not normally and homogeneously distributed followed by the Mann Whitney test.The test results showed that the combination of concentrations of arrowroot starch and taro starch binders had an effect on the physical characteristics, namely tablet hardness and brittleness and tablet disintegration time (p<0.05).
Pengaruh Perbedaan Konsentrasi Propilenglikol terhadap Karakteristik Fisik Hair Tonic Ekstrak Daun Katuk (Sauropus androgynus (L). Merr) Daradasih, Elline; Devi, Sisca
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.16825

Abstract

Katuk leaf extract contains flavonoids which can stimulate hair growth by relaxing the muscles in the blood vessels around the hair follicles. One dosage form that is suitable for hair growth application is hair tonic preparations. An important component in the formulation of hair tonic is a thickener which can maintain the stability of the preparation. Propylene glycol is a thickening agent that can determine the physical characteristics of hair tonic preparations which are related to the stability of the resulting preparations. The purpose of this study was to determine the effect of different concentrations of propylene glycol on the physical characteristics of hair tonic katuk leaf extract (Sauropus androgynus (L.) Merr). This type of experimental research uses a completely randomized design (CRD) one factorial. The independent variables in this study were the concentration of propylene glycol 5%, 15% and 25%. Testing the physical characteristics of hair tonic preparations included organoleptic, clarity, pH, viscosity, and specific gravity. Data analysis used the ANOVA test with a 95% level of confidence then continued with the Post hoc test. The results of the physical characteristic test showed that the difference in the concentration of propylene glycol in hair tonic katuk leaf extract had an effect on the physical characteristics of viscosity (p<0.05).
Pengaruh Konsentrasi Karbopol sebagai Emulgator terhadap Karakteristik Fisik Sediaan Lotion Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L.) Palma, Retno Dela; Devi, Sisca
Sinteza Vol. 5 No. 1 (2025): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i1.27305

Abstract

Starfruit leaf extract produces antioxidant activity from the flavonoid compound content. The lotion dosage form is one of the dosage forms used as an antioxidant application to the skin. The lotion formula consists of a water phase, an oil phase, and an emulsifier. The emulsifier is the most important part of the formation of lotion because it determines the physical characteristics produced and the stability of the preparation. Carbopol is a synthetic emulsifier that can absorb liquid and form a stable mass to produce stable physical characteristics of the lotion. The purpose of this study was to influence the concentration of carbopol on the physical attributes of starfruit leaf extract lotion and to determine the concentration of carbopol with the best physical characteristics of starfruit leaf extract lotion. This study is an experimental study with different concentrations of Carbopol, namely 0.3%; 0.4%; and 0.5%. The physical characteristics measured were organoleptic, pH, homogeneity, viscosity, spreadability, adhesion, protection power, and emulsion type. Viscosity and adhesion test data were tested using Kruskal Wallis and continued with Mann Whitney, while spreadability and protection test data were tested using ANOVA followed by Pos Hoc. The results showed that increasing the concentration of Carbopol affected protection power (p<0.05). The concentration of Carbopol that produced the best characteristics was 0.3% (formula 1).
Co-Authors Baiti, Hilma Nur Daradasih, Elline Palma, Retno Dela Widiyana, Widiyana