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All Journal e-CliniC Medical Scope Journal (MSJ) Jurnal Sosial dan Sains Blantika : Multidisciplinary Journal
Tandililing, Sherly
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Korelasi antara Kadar Kalsidiol (25-Oh) dan Rasio Netrofil-Limfosit dengan Keganasan Nodul Tiroid Bogar, Bryan D.; Lumintang, Nico; Tandililing, Sherly; Wariki, Windy M.
e-CliniC Vol. 12 No. 2 (2024): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v12i2.48492

Abstract

Abstract: Thyroid malignancy has shown the highest annual incidence rate. Vitamin D deficiency (serum 25-hydroxyvitamin D levels) is one of the risk factors for thyroid malignancy. The neutrophil-lymphocyte ratio (NLR) reflects the balance between pro-tumor inflammatory response and anti-tumor immune response. This study aimed to investigate the relationship between serum 25-hydroxyvitamin D levels, NLR, and thyroid nodule malignancy. This was an observational and analytical study with cross-sectional design. Samples were patients with thyroid nodules admitted to Prof. Dr. R. D. Kandou Hospital, Manado, form August 2022 to March 2023. The results obtained a total of 46 patients with thyroid malignancy that  met the inclusion criteria. The patient characteristics were predominantly female (82.6%), with a mean age of 50.2 ± 14.74 years, normal thyroid hormone status (82.6%), mean serum 25-hydroxyvitamin D levels of 32.25 ng/mL, mean NLR of 5, and papillary carcinoma as the most common malignancy (43.48%). Spearman's correlation analysis revealed a significant association between thyroid malignancy and serum 25-hydroxyvitamin D levels (r =-0.501, p=0) as well as NLR (r 0.376, p=0.01). In conclusion, serum 25-hydroxyvitamin D levels and NLR can be used as indicators for predicting thyroid nodule malignancy. Keywords: thyroid malignancy; 25-hydroxyvitamin D; neutrophil-lymphocyte ratio   Abstrak: Keganasan tiroid mengalami peningkatan angka kejadian tertinggi pertahun. Kekurangan vitamin D (kadar kalsidiol) merupakan salah satu faktor risiko terjadinya keganasan tiroid. Rasio netrofil limfosit (RNL) mencerminkan keseimbangan antara respon inflamasi protumor dan respon imun antitumor. Penelitian ini bertujuan untuk mengevaluasi hubungan antara kadar 25-hydroxyvitamin D serum dan RNL dengan keganasan nodul tiroid. Jenis penelitian ialah analitik observasional dengan desain potong lintang. Sampel penelitian ialah pasein dengan nodul tiroid yang dirawat di RSUP Prof. Dr. R. D. Kandou Hospital, Manado, sejak Agustus 2022 s/d Maret 2023. Hasil penelitian mendapatkan 46 pasien dengan keganasan tiroid yang memenuhi kriteria. Karakteristik sampel tebanyak ialah jenis kelamin perempuan (82,6%), rerata usia (50,2±14,74 tahun), status hormon tiroid normal (82,6%), rerata kadar 25-hydroxyvitamin D 32,25 ng/mL, rerata RNL 5, dan jenis keganasan karsinoma papiler (43,48%). Uji analisis Spearman menunjukkan keganasan tiroid secara bermakna berhubungan dengan kadar kalsidiol (r=-0,501, p=0), dan RNL (r=0,376, p=0,01). Simpulan penelitian ini ialah kadar 25-hydroxyvitamin D serum dan RNL dapat digunakan sebagai indikator untuk memrediksi keganasan nodul tiroid. Kata Kunci: keganasan tiroid; 25-hydroxyvitamin D; rasio netrofil-limfosit
Fraktur Komunitif Angulus – Korpus Mandibula dengan Pemasangan Titanium Miniplate dan Srew: Laporan Kasus Sitompul, Riston R.; Lumintang, Nico; Tandililing, Sherly
e-CliniC Vol. 12 No. 3 (2024): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v12i3.51821

Abstract

Abstract: Communitive fracture of the mandible is quite complicated to achieve good results with the use of titanium miniplates and screws. The challenges faced start from tips and tricks for placing non-rigid miniplate and screw fixation. There are two methods in performing mandibular communitive fracture surgery, namely closed reduction and open reduction. We reported a case of a 19-year-old male referred to Prof. Dr. R. Kandou Hospital, Manado, with open right mandible fracture. The patient was diagnosed with mild head injury, cerebral edema, skull base fracture, communitive fracture of mandibular angulus and corpus, non-displaced maxillary zygoma fracture, and palatal dental sagittal fracture. The patient underwent open reduction surgery with internal fixation using titanium miniplates and screws, and was re-evaluated in the first week after surgery up to three weeks after surgery. The patient's functional chewing and mouth opening were within normal limits. There were no complications such as infection or nerve lesions. In conclusion, communitive mandibular fracture using an open reduction technique with titanium miniplate and screw internal fixation gives satisfactory result. Keywords: communitive mandibular fracture; open reduction; dental occlusion   Abstrak: Fraktur komunitif mandibula merupakan kasus yang cukup rumit untuk mencapai hasil yang baik dengan penggunaan titanium miniplate dan screw. Tantangan yang dihadapi mulai dari tips dan trik penempatan fiksasi miniplate dan screw yang tidak rigid. Terdapat dua metode dalam melakukan operasi fraktur komunitif mandibula, yaitu reduksi tertutup dan reduksi terbuka. Kami melaporkan kasus seorang laki-laki 19 tahun dirujuk ke RSUP Prof. Dr. R. Kandou, Manado dengan patah tulang dagu kanan terbuka. Pasien didiagnosis dengan cedera kepala ringan, edema serebri, fraktur basis krani, fraktur angulus - korpus mandibula dekstra komunitif, fraktur zigoma pars maksilaris dekstra non-displaced, dan fraktur sagital dental palatal. Pasien dilakukan operasi reduksi terbuka dengan fiksasi internal. Evaluasi dilakukan pada minggu pertama paska operasi, hingga tiga minggu paska operasi. Didapatkan fungsional mengunyah dan membuka mulut pasien ini dalam batas normal, serta tidak didapatkan komplikasi seperti infeksi maupun lesi saraf. Simpulan kasus ini ialah fraktur mandibula komunitif dengan teknik reduksi terbuka dan fiksasi internal titanium miniplate dan screw memberikan hasil yang memuaskan. Kata kunci: fraktur mandibula komunitif; reduksi terbuka; oklusi dental
Co-Authors Akmal, Nuzly Q. Bogar, Bryan D. Edwin Z. Sipayung Johana Lintong, Pinkan Lumintang, Nico A. Nico Lumintang Papea, Melky Rendy Sitompul, Riston R. Sunarto Reksoprawiro Wariki, Windy M. V.