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Genipin Crosslinked Blended Collagen-Chondroitin: A Promising Biomaterial Scaffold Candidate for Cartilage Reconstruction Trimartani Trimartani; Normalina Sandora; Bambang Hermani; Jeanne A Pawitan; Raden Ayu Anatriera
HAYATI Journal of Biosciences Vol. 29 No. 2 (2022): March 2022
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.29.2.122-128

Tissue engineering offers a solution to the shortage of materials for cartilage reconstruction surgery by providing various potential biomaterial scaffolds. Tissue engineering utilizes biological or synthetic biomaterials as a scaffold for the host cells to repopulate and regenerate the tissue. The natural biomaterials such collagen and chondroitin imitates native cartilage matrix composition. Genipin as one of natural crosslinkers was added to improve the matrix biomechanical properties. This study was done to investigate biocomposition of blended collagen type 1, collagen type 2, chondroitin sulphate (Col1-Col2-CS) and genipin for its cytotoxicity using human umbilical mesenchymal stem cells (hUCMSCs), surface morphology, and biochemical composition. Genipin-crosslinked collagen-chondroitin biocomposite showed a homogeneous shape while uncrosslinked biocomposite had rough surface and fibrillar folds size. Spectroscopy demonstrated both biocomposites had similar peak resemble to no alternation of the biocomposition by crosslinking. Both types of biocomposites were biocompatible and had no toxic effects, as compared to the cell colony only (p value = 0.26). The conclusion are blended composite of collagen chondroitin crosslinked with genipin had generated a fine microstructure scaffold with smaller pore size, had similar biomolecular component spectrum absorption, and no exhibition of residual toxicity.

Rinoplasti pada kelainan hidung kongenital Trimartani Trimartani; Novra Widayanti
Oto Rhino Laryngologica Indonesiana Vol 45, No 1 (2015): Volume 45, No. 1 January - June 2015
Publisher : PERHATI-KL

Latar belakang: Nasal bifida dan supernumerary nostril merupakan kelainan hidung kongenital yang sangat jarang. Nasal bifida disebut juga hidung ganda atau celah hidung, mempunyai manifestasi sangatberagam mulai dari lekukan minimal pada puncak hidung hingga celah maksila. Supernumerary nostrilmerupakan bagian dari kelainan duplikasi hidung. Tujuan: Sebagai ilustrasi kepada ahli THT-KL mengenaikasus kelainan hidung kongenital yang jarang ditemukan. Kasus: Dilaporkan tiga kasus anak dengankelainan hidung kongenital selama bulan Agustus-Desember 2012. Satu kasus dengan nasal bifida, satukasus dengan nasal bifida disertai atresia koana, dan satu kasus dengan triple nostril. Penatalaksanaan:Pada kasus nasal bifida dilakukan rekonstruksi hidung menggunakan tandur dermis dan pada kasustriple nostril dilakukan fistulektomi dan rekonstruksi alae. Kesimpulan: Nasal bifida dan triple nostrilmerupakan kelainan hidung kongenital yang jarang ditemukan. Kelainan ini membutuhkan rekonstruksiyang optimal. Indikasi waktu dari operasi pada kasus kelainan hidung kongenital ini berdasarkan ukuranhidung menyerupai ukuran dewasa dan perkembangan sosial anak. Kata kunci: kelainan hidung kongenital, nasal bifida, supernumerary nostril, duplikasi hidungABSTRACT Background: Bifid nose and supernumerary nostril are rare nasal congenital anomalies. The appearance of bifid nose, also called double nose or cleft nose, varies from a simple groove at thenasal apex to a maxillary cleft. Supernumerary nostril is a kind of nasal duplication. Purpose: Thiscase report is to forewarn general practitioners and ENT specialist about these rare nasal congenitalanomaly cases. Case: Reported three cases with congenital nasal anomaly, one case with bifid nose, onecase with bifid nose and choanal atresia, and one case with triple nostril. Management: The cases withbifid nose underwent nasal reconstruction using dermal graft and the case with triple nostril underwentfistulectomy and alae reconstruction. Conclusion: Bifid nose and triple nostril are rare nasal congenitalanomaly that need optimal reconstruction. Indication for the time of the operation for cases of congenitalnasal deformities is based on the size approaching the adult size and on the child’s social development. Keywords: congenital nasal anomaly, bifid nose, supernumerary nostril, nasal duplication

Retroauricular Advancement Flap In Single Stage Auricular Defect Reconstruction Mirta Hediyati Reksodiputro; Trimartani Koento; Dwi Wahyu Manunggal
eJournal Kedokteran Indonesia Vol 9, No. 2 - Agustus 2021
Publisher : Faculty of Medicine Universitas Indonesia

Auricular defects must be treated early and properly because they may interfere with facial symmetry. Retroauricular skin is an ideal flap source for a non-reduction reconstruction procedure of the upper, middle, and lower auricular defects. Auricular reconstruction aims to achieve good anthropometric and aesthetic ear unit. The purpose of this case report is to present a reconstruction of auricular defects using the rectroauricular flap that results in a favorable aesthetic and normal anthropometric dimensions of the auricular. We report a case of auricular defect caused by post-excision of keloid located in the helical and antithetical area of the middle third of the right auricular, using a retroauricular flap. Normal values of the auricular’s anthropometric measurements were achieved, followed by a complete aesthetic ear unit. Retroauricular flaps are suitable for reconstructing partial auricle defects in the helical rim, temporal area, and conchae. Keywords: auricular defect, retroauricular flap, aesthetic ear unit, auricular anthropometry. Jabir Retroaurikular untuk Rekonstruksi Defek Telinga Abstrak Daun telinga berperan penting pada simetri wajah sehingga defek di daun telinga harus ditangani dengan baik sejak dini. Kulit retroaurikular merupakan sumber jabir ideal untuk rekonstruksi tanpa reduksi pada defek daun telinga bagian atas, tengah, dan bawah. Rekonstruksi daun telinga bertujuan untuk mendapatkan hasil yang baik secara antropometri dan estetika unit telinga. Tujuan laporan kasus ini adalah menunjukkan hasil yang baik berdasarkan unit telinga estetik dan dimensi normal antropometri pada rekonstruksi defek daun telinga menggunakan jabir rektroaurikular. Dilaporkan satu kasus defek telinga pasca-eksisi keloid, di area heliks dan antiheliks sepertiga tengah daun telinga kanan, menggunakan jabir retroaurikular. Didapatkan nilai normal pada pengukuran antropometri telinga dan kelengkapan estetika unit telinga. Jabir retroaurikular baik untuk rekonstruksi defek telinga parsial di lengkung heliks, area temporal, dan konka. Kata kunci: defek aurikular, jabir retroaurikular, unit telinga estetik, antropometri daun telinga.

Analysis of Internal Nasal Valves Shapes and Angle due to Nasal Obstruction in Asian Nose Tiara Melati; Mirta Hediyati Reksodiputro; Trimartani Koento; Sandi Iljanto
eJournal Kedokteran Indonesia Vol 10, No. 3 - Desember 2022
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.10.203.212-8

BACKGROUND Internal nasal valve (INV) is widely discussed because it is believed to have a role in structural nasal obstruction. Caucasian has a rather acute angle of INV due to the known geometric of their nose. Whilst Asian generally has broader, thicker, and bigger anthropometric proportion of nose than Caucasian. Asia is vastly diverse in ethnicity, one can only assume that Asian INV may be differ in shape and larger in angles compare to Caucasian, due to the minimum publication addressing this issue. AIM To report the anatomy of INV and its angle in obstructed Asian noses. METHOD A case control study was conducted. Forty cases of nasal obstruction and 80 controls without nasal obstruction. Both groups were evaluated using Nasal Obstruction Symptom Evaluation (NOSE) questionnaire, rigid nasal endoscopy and active anterior rhinomanometry (AAR). Anatomy and angle of INV was later measured using digital image analysis. RESULT Six basic INV shapes were seen throughout both groups, many has different shape combinations. Most commonly (more than 60%) observed shape in both groups were the occupied by nasal septal body (NSB). The right INV angle in case group was 15,5º ± 10,1º (p = 0,123) and left INV angle was 17,2º ± 9,0º (p = 0,022). In control group, the right INV angle was 19,6º ± 11,8º (p = 0,123) and left INV angle was 23,2º ± 12,5º (p = 0,022). CONCLUSION It is shown that most common shape of Asian INV in both groups, is the occupancy by NSB. Internal nasal valve angle in obstructed nose is narrower in comparison to those without nasal obstruction. This study also demonstrates Asian, particularly Indonesian, has a wider angle than Caucasian.

Vocal cord immobility after lateral pharyngotomy extraction of the impacted dentures in the upper esophagus: A Case Report Tamin, Susyana; Koento, Trimartani; Hutauruk, Syahrial Marsinta; Supit, Ivana; Ardiantara, Sabda
Dentika: Dental Journal Vol. 27 No. 1 (2024): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v27i1.15716

Impaction of foreign bodies in the esophagus is a frequent emergency in otorhinolaryngology. However, diagnosing and managing denture impaction in the esophagus presents greater challenges compared to other foreign bodies, often leading to various complications. This study reported a rare case of vocal cord immobility after the evacuation of denture impaction in the esophagus using lateral pharyngotomy. The patient, a 73-year-old man, experienced throat discomfort after swallowing a denture an hour before admission. According to the CT scan carried out, a 3.7 cm long denture was found around the T3-T5 spine level and was located 3 mm lateral right to the descendant aorta and 4 mm posterior of the trachea. During esophagoscopy extraction, the denture was stuck in the upper esophagus and was successfully evacuated by lateral pharyngotomy. Subsequently, the patient developed vocal cord immobility, and this case underscores the importance of considering vocal cord complications following the extraction of a denture impaction in the esophagus.

Appropriate imaging in the management of first branchial cleft anomalies Koento, Trimartani; Sari, Indira
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 2 (2023): VOLUME 53, NO. 2 JULY - DECEMBER 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i2.624

Background: First branchial cleft anomalies (FBCA) are rare clinical entities of the head and neck.The low incidence and varied presentation often result in misdiagnosis and inappropriate treatment.Correct diagnosis is essential for proper management, while an incorrect diagnosis will often lead toinadequate treatment. A good understanding of the regional anatomy and embryology can lead to anearly diagnosis and thereby effective management of FBCA. Purpose: To present how to diagnose andmanage FBCA. Case report: A case of a 6-year-old female who had an FBCA with a history of swellingand recurrent discharge from the fistula in the infra-auricular area. Complete excision of the tract wasperformed without facial nerve complication. Clinical question: What is the appropriate imaging fordiagnosis FBCA? Review method: Scoping review was done to identify the scientific evidence aboutimaging for diagnosis FBCA. Systemic searching in 4 databases (PubMed, Embase, Proquest, and Webof Science) using keywords “first branchial cleft”, “anomaly”, and “imaging”. Result: Three article wasfound relevant with the topic of imaging for diagnosis FBCA. Conclusion: Proper diagnosis of FBCAcan lead to proper management and good results. Imaging can provide an anatomical picture of eachbranchial arch anomaly, which can be very helpful in preoperative planning to determine a definitivesurgical approach. Early management of FBCA can reduce the recurrence rate significantly.Keywords: first branchial cleft, anomaly, children, imaging

Appropriate imaging in the management of first branchial cleft anomalies Koento, Trimartani; Sari, Indira
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 2 (2023): VOLUME 53, NO. 2 JULY - DECEMBER 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i2.624

Background: First branchial cleft anomalies (FBCA) are rare clinical entities of the head and neck.The low incidence and varied presentation often result in misdiagnosis and inappropriate treatment.Correct diagnosis is essential for proper management, while an incorrect diagnosis will often lead toinadequate treatment. A good understanding of the regional anatomy and embryology can lead to anearly diagnosis and thereby effective management of FBCA. Purpose: To present how to diagnose andmanage FBCA. Case report: A case of a 6-year-old female who had an FBCA with a history of swellingand recurrent discharge from the fistula in the infra-auricular area. Complete excision of the tract wasperformed without facial nerve complication. Clinical question: What is the appropriate imaging fordiagnosis FBCA? Review method: Scoping review was done to identify the scientific evidence aboutimaging for diagnosis FBCA. Systemic searching in 4 databases (PubMed, Embase, Proquest, and Webof Science) using keywords “first branchial cleft”, “anomaly”, and “imaging”. Result: Three article wasfound relevant with the topic of imaging for diagnosis FBCA. Conclusion: Proper diagnosis of FBCAcan lead to proper management and good results. Imaging can provide an anatomical picture of eachbranchial arch anomaly, which can be very helpful in preoperative planning to determine a definitivesurgical approach. Early management of FBCA can reduce the recurrence rate significantly.Keywords: first branchial cleft, anomaly, children, imaging

Otoplasty in Children with Prominent Ears: A Scoping Review Handari, Eva Tami; Koento, Trimartani
Oto Rhino Laryngologica Indonesiana Vol. 55 No. 2 (2025): VOLUME 55, NO. 2 JULY - DECEMBER 2025
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v55i2.750

Background: Prominent ears are one of the most common facial deformities in children. Although primarily a cosmetic issue, this condition can have significant social and psychological impacts on children, leading to the need for otoplasty at an early age. Otoplasty, a corrective surgical procedure, has undergone various innovations aimed at achieving satisfactory aesthetic outcomes, while minimizing complications. Purpose: To convey surgical techniques used in otoplasty for children with prominent ears. Case report: A 5-year-old patient presented with complaints of absent external auditory canals and prominent ears. The patient was diagnosed with bilateral auricular atresia, and prominent ears. The parents also reported speech delay in their child. Otoplasty was performed using the latest technique, with adjustments to the antihelical fold and reduction of conchal projection. Result: Following otoplasty using the newly introduced setback otoplasty technique described by Raunig, the patient demonstrated significant improvement in the aesthetic appearance of the ears with a more harmonious projection. Postoperative complications were minimal, with no signs of infection or residual deformity. The patient also continued postoperative speech therapy to address the speech delay. Conclusion: Advances in otoplasty with the New Concept Rauning technique had proven effective in correcting prominent ear deformities in children, yielding favorable aesthetic outcomes, with minimal complications. Early otoplasty can correct ear shape abnormalities and improve the child’s quality of life, both cosmetically and psychosocially.

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