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All Journal Jurnal Ilmu Dasar Jurnal Teknologi dan Manajemen Industri Terapan
Rahmayanti, Fina
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Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Engineering Industrial & Manufacturing Engineering Mathematics

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Perancangan dan Pengembangan Treker Shock Breaker dengan Pendekatan Metode Rasional Anwardi; Nadia Gita Pratiwi; Wibowo, Ryan Prayoga; Meiliati, Herriyzka; Akbar, Prama Muadzin; Rahmayanti, Fina
Jurnal Teknologi dan Manajemen Industri Terapan Vol. 3 No. 3 (2024): Jurnal Teknologi dan Manajemen Industri Terapan
Publisher : Yayasan Inovasi Kemajuan Intelektual

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55826/jtmit.v3i3.305

Abstract

Usaha Mikro Kecil Menengah (UMKM) memainkan peran penting dalam kemajuan ekonomi dan teknologi di Indonesia, khususnya dalam menciptakan peluang kerja dan inovasi yang terus meningkat setiap tahun. Bengkel Motor ABC, salah satu UMKM yang bergerak di bidang otomotif, menawarkan jasa servis pemasangan dan penggantian shock breaker. Namun, proses pembukaan shock breaker di Bengkel Motor ABC masih menggunakan alat treker tradisional yang berisiko menyebabkan goresan pada shock breaker dan cedera pada tenaga kerja. Penelitian ini bertujuan untuk merancang dan mengembangkan alat treker shock breaker yang lebih aman dan efisien menggunakan metode rasional. Hasil pengembangan mencakup penambahan dua penyangga di bagian atas, dua pengunci, serta bantalan pada body treker yang dilapisi plat baja pada lubang tempat peletakan shock breaker. Uji coba dilakukan pada 40% dari 50 bengkel servis motor, dengan hasil menunjukkan peningkatan efisiensi kerja rata-rata sebesar 52,51%. Hasil ini menunjukkan bahwa pengembangan alat treker shock breaker memberikan dampak positif, memudahkan pekerja, dan meningkatkan keselamatan kerja.
The Binding Prediction of 6-Paradol and its Derivatives on TRPV1 Agonist as a New Compound for Treating Painful Diabetic Neuropathy Fajrin, Fifteen Aprila; Rahmayanti, Fina; Pratoko, Dwi Koko
Jurnal ILMU DASAR Vol 21 No 2 (2020)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jid.v21i2.15501

Abstract

Ginger was reported to have a suppressive effect on pain in patients with Painful Diabetic Neuropathy (PDN). Our latest study revealed that 6-shogaol, one of the ginger components, had the best affinity in the Transient Receptor Potential Vanilloid 1 (TRPV1), a key receptor in PDN). Paradol, which obtained from gingerol and shogaol metabolism, also had potent activities in several diseases, compared to the other derivatives of gingerol and shogaol. However, shogaol and paradol is very similar in chemical structure with only different in one double bond in 4-5 position. Until now there is no explanation about paradol mechanism in TRPV1. Based on this, our study was designed to predict the activity of 6-paradol and its derivatives to TRPV1 as target receptor in PDN using in-silico model. 2-paradol, 4-paradol, 6-paradol, 8-paradol and 10-paradol were used as ligands. Capsaisin, the agonist of TRPV1, was used as a native ligand in this study. TRPV1 was obtained from protein data bank (PDB). Ligand bond prediction and affinity was performed using Molegro Virtual Docker. The results showed 2-paradol, 4-paradol, 6-paradol, 8-paradol and 10- paradol had good affinity against TRPV1. These result indicated that 6-paradol and the derivatives had potential as a drug compound for PDN therapy.Keywords: ginger, 6-paradol, painful diabetic neuropathy, trpv1.
Co-Authors Akbar, Prama Muadzin Anwardi Fifteen Aprila Fajrin Meiliati, Herriyzka Nadia Gita Pratiwi Wibowo, Ryan Prayoga