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All Journal JSMARTech : Journal of Smart Bioprospecting and Technology RESLAJ: Religion Education Social Laa Roiba Journal
Mawaddani, Nala
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Religion Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Social Sciences

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IN SILICO STUDY OF CENTELLA ASIATICA ACTIVE COMPOUND AS BACE1 INHIBITOR IN ALZHEIMER’S DISEASE Mawaddani, Nala; Wibowo, Natalia RK; Nadhira, Qumaira HH; Pramifta, Ratih Ayu
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 1, No 2 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (464.148 KB) | DOI: 10.21776/ub.jsmartech.2020.001.02.3

Abstract

Alzheimer (AD) is a chronical neurodegenerative disease which is the 6th leading cause of death worldwide. About 36 million cases in the world and may increase to 115 million in 2050. The pathological cause of AD is the presence of residual A? peptides. A? peptides is produced in the cleavage process of the amyloid precursor protein (APP) sequentially by Beta amyloid precursor protein cleavage enzyme 1 (BACE1) and ?-secretase. Flavonol, germacrene B, and  sitosterol are compounds found in Centella asiatica which is has potential as BACE1 inhibitor. The aim of this study was to analyze the interaction between BACE1 with  flavonol, germacrene B and sitosterol  by molecular docking to predict the BACE1 inhibitor potent of those compound. We obtained BACE1 from RSCB database, flavonol, germacrene B  and  sitosterol from PubChem database. Molecular dockcing was done using Hex 8.0.0. The docking result were vizualized with Discovery Studio 3.5. Interaction of BACE1 resulted binding energy for sitosterol was-239,7 kcal/mol, flavonol was -188,1 kcal/mol, and germacrene B was -185,6 kcal/mol. Flavonol and sitosterol bound to the active site of BACE1 involving  Thr232 and Ile110 on flavonol,  while Tyr71 on sitosterol. All of the active compounds didn?t have the interaction at S1? subsite,which is the center of BACE1 active site which has become the key of APP activation from BACE1. This study has shown that flavonol  and sitosterol had potential to reduce BACE1 activity but not directly inhibit BACE1 activity.
Kondisi Geografis yang dapat Menyebabkan Fenomena Frostbite : Systematic Review Salsabillah, Umi; Mawaddani, Nala; Anggraini, Dwi Putri; Algazali, Mohamad Assegaf; Fadillah, Muhammad Alif
Reslaj: Religion Education Social Laa Roiba Journal Vol. 6 No. 12 (2024): RESLAJ: Religion Education Social Laa Roiba Journal 
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/reslaj.v6i12.5054

Abstract

This study aims to systematically review scientific journals that discuss the relationship between geographical conditions and the occurrence of frostbite. The method used is a Systematic Literature Review, structured according to the Preferred Reporting System for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered in PROSPERO (CRD42020136170). Primary data was collected from three scientific databases: PubMed, Science Direct, and Google Scholar. Articles meeting the criteria were analyzed, focusing on the geographical conditions of countries at risk for frostbite. Out of 226 identified studies, only 14 articles met the criteria for further analysis. The results show that countries with cold seasons, temperatures below 0°C, strong winds, and inadequate self-protection are at higher risk of frostbite. Frostbite commonly affects adults to the elderly who continue outdoor activities in cold conditions with insufficient body protection. In conclusion, geographical conditions play a crucial role in increasing frostbite risk. Low temperatures, extreme weather, and public awareness of self-protection are the main factors contributing to frostbite occurrences in various regions.
Comparative Study of Sampling Technique, Surface Type, and DNA Quantity in Touch DNA: A Systematic Review Mawaddani, Nala
Reslaj: Religion Education Social Laa Roiba Journal Vol. 7 No. 2 (2025): RESLAJ: Religion Education Social Laa Roiba Journal
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/reslaj.v7i2.5673

Abstract

Touch DNA analysis has become increasingly important in forensic investigations. This systematic review aims to compare the effectiveness of various sampling techniques on different surface types and examine the concentration of DNA obtained. Following PRISMA guidelines, relevant studies were identified through PubMed, Scopus, and Web of Science databases. Data were extracted using NVivo and synthesized using a narrative approach, while study quality was assessed using the Mixed Methods Appraisal Tool (MMAT). Swabbing, particularly double swabbing, was the most common technique. However, tape lifting was more effective on porous/uneven surfaces, and wet-vacuum sampling outperformed double swabbing on brick. DNA concentrations varied (0.002−0.707 ng/μL) based on surface type and sampling method. Findings provide guidance for forensic practitioners in selecting optimal sampling techniques, refining DNA extraction protocols, and interpreting results. Nevertheless, methodological heterogeneity and laboratory focus limit generalizability. This review offers a comprehensive understanding of factors influencing touch DNA analysis success. Future research should focus on larger, standardized studies, novel sampling techniques, and advanced DNA analysis methods to address challenges associated with degraded or limited touch DNA samples. Continued research is crucial for enhancing the reliability and applicability of touch DNA evidence in forensic investigations.
Co-Authors Algazali, Mohamad Assegaf Anggraini, Dwi Putri Fadillah, Muhammad Alif Nadhira, Qumaira HH Pramifta, Ratih Ayu Salsabillah, Umi Wibowo, Natalia RK