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All Journal APTEK JSMARTech : Journal of Smart Bioprospecting and Technology Jurnal Riset Ekonomi dan Bisnis Mahasiswa : Brainy Jurnal Pengabdian Masyarakat
Hermawan, Muhammad
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Engineering Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Social Sciences

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ANALYSIS OF ALLOPURINOL, CUCURBITACIN B, MORINDINE, AND PIPERINE AS XANTHINE OXIDASE INHIBITOR BY MOLECULAR DOCKING Fitria, Lailatul; Hermawan, Muhammad; Sakti, Sefihara Paramitha
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 1, No 1 (2019)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.5 KB) | DOI: 10.21776/ub.jsmartech.2019.001.01.2

Abstract

Xanthine oxidase (XO) is known to be involved in the mechanism of ROS and oxidants production.  XO inhibitor plays role in preventing changes in purines to uric acid so uric acid levels in serum and urine can be reduced. The aim of this study was to analyze the interactions between XO and allopurinol, cucurbitacin B, morindin, or piperine by molecular docking. We obtained XO (1FIQ), allopurinol (CID135401907), cucurbitacin B (CID5281316), morindin (CID151621), and piperine (CID638024) from the database.  Molecular docking was done using Hex 8.0. The docking results were visualized with Discovery Studio 3.5. The interaction of cucurbitacin B with XO and morindin with XO resulted in low docking energy, -375.08 kcal/mol and -377.4 kcal/mol. The docking energy of piperine with XO and allopurinol with XO was -163.32 kcal/mol and -281.4 kcal/mol. Cucurbitacin B and morindin bound to the active site of XO precisely on the FAD domain involving ARG426, ALA338, and ASP360. Both of the compounds established more than 10 bonds of van der waals when interacted with XO. Piperine and allopurinol bound to XO near the Fe2S cofactor. This study suggests that cucurbitacin B and morindin may have high potential as xanthine oxidase inhibitors.Keywords: allopurinol, cucurbitacine B, morindin, piperin, xanthine oxidase
DAMPAK STRUKTUR MODAL TERHADAP PROFITABILITAS PERUSAHAAN (STUDI KASUS PT SRI REJEKI ISMAN TBK TAHUN 2017-2022) Hermawan, Muhammad
Brainy: Jurnal Riset Mahasiswa Vol 4 No 2 (2023): Jurnal Riset Ekonomi dan Bisnis Mahasiswa Edisi Desember 2023
Publisher : Fakultas Ekonomi dan Bisnis Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/brainy.v4i2.75

Abstract

The purpose of this study is to determine the impact of capital structure on company profitability. The method used in this research uses quantitative methods with a descriptive approach, the type of data used in this study is quantitative data. The data source used in this study is secondary data. Secondary data is a source of research data obtained by researchers indirectly through intermediary media obtained. Secondary data is a source of research data obtained by researchers indirectly through intermediary media obtained. The technique of collecting research data is by documentation method. The data sources used in this study are from the Indonesia Stock Exchange (IDX) and annual financial reports. Population is a generalization consisting of objects / subjects that have certain qualities and characteristics that are determined by researchers to be studied and then drawn conclusions. The results of a simple regression analysis test using a partial t test showed a capital structure value of 0.201 which is greater than the predetermined significance therapy of 0.05, then this has no significant relationship or influence on the dependent variable y  profitability, then in this variable H0 is accepted and Ha is rejected.  The cause of no significance or no influence or relationship of capital structure variables on profitability can be caused by other variables not mentioned in this study and various other internal and external factors that have nothing to do with this study.
Inovasi Pemanfaatan Limbah Kulit Kopi Menjadi Produk Yang Bernilai Tinggi Sebagai Pengembangan Produk Pada Gapoktan Desa Mulyorejo Oktavinda, Diana; Dwi Natasya, Amelia; Syaifuddin, Ageng; Daffa Duta Perdana, Mohammad; Narisa, Defani; Angga Pranadaning, Fadila; Zahro Alifia Rohma, Sofiatus; Edwar Yudhistira, Gedion; Aini, Arifatul; Nurfaizeh, Nurfaizeh; laili, Nufilatul; Shofyan, Firdaus; Hermawan, Muhammad; Afreyna Fauziah, Difari
JURNAL PENGABDIAN MASYARAKAT (JPM) Vol 3 No 2 (2023)
Publisher : Institut Teknologi dan Sains Mandala

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Abstract

Coffee is one of the plantation commodities that has quite high economic value among other plantation crops such as cocoa and tea. One of the villages as a smallholder coffee producer is the village of Mulyorejo. Mulyorejo Village is the largest coffee producing village out of nine villages in Silo District, Jember Regency. So far, coffee pod waste has caused many problems in its handling and is left to rot, stacked and burned, all of which have a negative impact on the environment, so we need to think about countermeasures. Coffee skin waste has the potential to be processed back into a product because it has a fairly high economic value. The activities carried out were in the form of counseling and demonstrations on the manufacture and introduction of Coffee Skin Tea products. The purpose of holding counseling activities is to increase target knowledge about the potential of coffee skin waste, the processing system of coffee skin waste, the benefits of coffee skin waste for health, and the nutritional content of coffee skin waste.
Creating a Vertical Peeling Apparatus for Young Jackfruit Skins Employing Turning Process Technology Hermawan, Muhammad; Ma'a, Mustaza; Yanda Zaira, Jupri; Wijianto, Agus
Aptek Jurnal Apliksai Teknologi (APTEK): Volume 17, No. 02, Juni 2025
Publisher : Fakultas Teknik Universitas Pasir Pengaraian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30606/aptek.v17i2.3178

Abstract

Young Jackfruit (Artocarpus heterophyllus) is a tropical fruit that grows in various regions, including Southeast Asia. While typically harvested when ripe, it is also consumed in its young stage. This final project focuses on the design and development of a Vertical Young Jackfruit Skin Peeling Machine utilizing the Turning Process Method. The proposed peeling machine is powered by a 1 hp motor with a speed of 1450 rpm, which is transmitted to 100 rpm. The machine's driving mechanism comprises a single transmission system, consisting of a pair of pulleys connected by a V-belt. When the motor is activated, the rotation is directly transmitted from pulley 1 to pulley 2, mounted on a 25 mm diameter shaft that rotates the young jackfruit using a V-belt intermediary. As the shaft rotates, a knife applies pressure on the rotating young jackfruit, moving from bottom to top. This movement is facilitated by a threaded shaft mechanism driven by the rotation of the fruit-driving shaft, which receives the rotational transmission from pulley 1 to pulley 2, mounted on a 25 mm diameter shaft to a 17 mm diameter shaft with a rotational speed of 40 rpm. The peeling process is conducted according to the dimensions of the young jackfruit, from bottom to top.
Co-Authors Aini, Arifatul Angga Pranadaning, Fadila Daffa Duta Perdana, Mohammad Dwi Natasya, Amelia Edwar Yudhistira, Gedion Fauziah, Difari Afreyna Fitria, Lailatul laili, Nufilatul Ma'a, Mustaza Narisa, Defani Nurfaizeh, Nurfaizeh Oktavinda, Diana Sakti, Sefihara Paramitha Shofyan, Firdaus Syaifuddin, Ageng Wijianto, Agus Yanda Zaira, Jupri Zahro Alifia Rohma, Sofiatus