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Ozveren, Neslihan
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Dentistry

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Gingival Enlargement in Patients who Have Undergone Renal Transplants: A Meta-Analysis Serindere, Gozde; Ozveren, Neslihan
Journal of Dentistry Indonesia Vol. 25, No. 2
Publisher : UI Scholars Hub

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Abstract

Severe gingival enlargement (GE) is one of the most commonly observed adverse effects in patients who have undergone renal transplants due to the use of cyclosporine A. Objectives: We aimed to gain more insight into the prevalence of GE in patients with renal transplants. Methods: We searched the PubMed and Web of Science databases for relevant studies from January 1990 to January 2018. Using random effects models, we calculated summary incidence rates and 95% confidence intervals (CIs). Results: A total of 595 patients from 10 studies were included. Patients using cyclosporine A with or without any other drugs had a 62.6% (95% CI, 41.9%–79.5%) incidence of GE. Subgroup analysis according to diagnostic criteria showed that the incidence of GE was lower when using well-defined diagnostic criteria or scoring system. The incidence of GE was 88.2% (95% CI, 80.9%–93.0%) in patients using cyclosporine A with nifedipine. Cyclosporine A without nifedipine was associated with a significantly decreased risk of GE incidence when compared with the combination of cyclosporine A and nifedipine (odds ratio: 0.198; 95% CI, 0.083–0.473; P < 0.001). Conclusions: It is important for all clinicians to know the effects of the aforementioned drugs and the treatment options.
Effect of Acid Etching and Er:YAG Laser Enamel Conditioning on the Microleakage of Glass Carbomer Fissure Sealants Ozveren, Neslihan; Uslu, Yesim Sesen; Donmez, Nazmiye
Journal of Dentistry Indonesia Vol. 27, No. 1
Publisher : UI Scholars Hub

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Objective: This study aimed to evaluate the effects of Er:YAG laser used alone or in combination with acid etching as surface conditioners on the microleakage of a glass carbomer fissure sealant for permanent molar teeth. Methods: Forty sound human permanent molar teeth were randomly divided into four experimental groups based on enamel etching methods: group I, no surface conditioning; group II, 37% phosphoric acid etching; group III, Er:YAG laser etching; and group IV, sequential laser etching and acid etching. After surface conditioning procedures were conducted, the teeth were sealed with a glass carbomer seal. The teeth were subjected to thermocycling with 2500 cycles at 5±2 °C to 55±2 °C for 24 h. Subsequent microleakage was assessed via dye penetration under a stereomicroscope. Results: Group II showed the lowest microleakage scores. Groups III and IV exhibited similar score distribution, which was lower than that of group I. Conclusions: Laser etching and acid etching decrease the microleakage probability of glass carbomer sealants, and acid etching alone provides a more suitable surface for these sealants. Sequential laser etching and acid etching have no additional benefit in comparison with acid etching alone and yield worse results than those of the other tested methods.
Co-Authors Donmez, Nazmiye Serindere, Gozde Uslu, Yesim Sesen