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All Journal Indonesian Journal of Cancer Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Handayani, Rosmeri
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Profil Bakteri dan Pola Sensitivitas Antibiotik pada Pasien Pneumonia Terkait Ventilator di Rumah Sakit Tersier ICU di Jawa Barat, Indonesia Handayani, Rosmeri; Hamidie, Ronald
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 3 No. 2 (2025)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/bikkm.vol3.iss2.art2

Abstract

Latar Belakang: Pneumonia terkait ventilator (VAP) merupakan infeksi nosokomial yang sering terjadi di ICU, meningkatkan mortalitas, lama rawat inap, dan biaya perawatan. Penggunaan antibiotik yang tidak rasional dapat memperburuk resistensi bakteri. Tujuan :  menganalisis pola bakteri dan profil kepekaan antibiotik pada pasien VAP di rumah sakit tersier di Indonesia guna mengoptimalkan terapi empiris dan pencegahan resistensi. Metode: Penelitian deskriptif retrospektif dilakukan dengan menganalisis data kultur sputum dan uji sensitivitas antibiotik dari pasien VAP di ICU periode Maret–Agustus 2024. Data diolah secara statistik deskriptif untuk mengidentifikasi pola bakteri dan resistensi antibiotik. Hasil: Dari 46 sampel, 43 (93,5%) positif bakteri, didominasi Gram-negatif (78,26%), terutama Acinetobacter baumannii (38,1%), Pseudomonas aeruginosa (16,7%), dan Klebsiella pneumoniae (9,5%). Terdapat resistensi tinggi terhadap beberapa antibiotik lini pertama. Simpulan: Bakteri Gram-negatif merupakan patogen utama VAP dengan tingkat resistensi antibiotik yang bervariasi. Diperlukan strategi pencegahan infeksi dan penggunaan antibiotik secara rasional untuk menekan laju resistensi di ICU. Kata Kunci: Pola bakteri; Unit Perawatan Intensif; Kepekaan; Pneumonia terkait ventilator
Simultaneous Presentation of Follicular Lymphoma and Diffuse Large B-cell lymphoma (DLBCL): A Case Report Handayani, Rosmeri; Kosasih, Agus Susanto
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1364

Abstract

Introduction: The natural history of follicular lymphoma (FL) is frequently characterized by transformation to a more aggressive diffuse large B-cell lymphoma (DLBCL). Outcomes of patients with histologic transformation (HT) of FL have been believed to be poor. However, a leucocytosis at presentation is infrequently described. In this report, we present a case of simultaneous presentation of follicular lymphoma and DLBCL.Case Presentation: A 50-year-old male patient presented to a head and neck specialist with complaints of slowly progressing swelling in the nose on the left side for a duration of 1 year, diagnosed with nasofarynx carcinoma. After excision surgery, the patient was referred to an internist for follow-up on the leukocytosis. Biopsy and immunohistochemistry from the nose and tonsil were suggestive of DLBCL. However, bone marrow aspiration was suggestive of follicular lymphoma. After a complete work-up, he was diagnosed with DLBCL and was treated with six cycles of the standard (CHOP) regimen. The patient’s history revealed a leukocytosis for 4 years prior to cardiac catheterization.Conclusion: These findings suggest a clonal relationship between the two types of lymphoma cells. Furthermore, they support the transformation of an acute follicular lymphoma into a composite lymphoma combining a high-grade B-cell lymphoma. Understanding the natural history of follicular lymphoma can aid the diagnosis and implies a worse prognosis in patients compared to de novo DLBCL.
Co-Authors Agus Susanto Kosasih, Agus Susanto Hamidie, Ronald