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All Journal Muhammadiyah Journal of Geriatric Cermin Dunia Kedokteran Scientific Journal
Adnyani, Ni Made Dwi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Keganasan Kolorektal dengan Fenomena Raynaud Sekunder Adnyani, Ni Made Dwi; Nugraha, Ida Bagus Aditya; Kambayana, Gede
Cermin Dunia Kedokteran Vol 46, No 12 (2019): Kardiovaskular
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (698.372 KB) | DOI: 10.55175/cdk.v46i12.399

Abstract

Penyakit Raynaud adalah penyakit vaskular primer yang ditandai dengan spasme temporer arteri kecil dan arteriol, biasanya di jari tangan atau, yang lebih jarang, jari kaki. Penyebab penyakit Raynaud dapat primer atau sekunder; salah satu penyebab sekunder adalah proses malignansi. Dilaporkan kasus Fenomena Raynaud Sekunder diduga akibat kanker kororektal pada laki-laki, 46 tahun, suku Jawa.Raynaud's disease is a primary vascular disease characterized by temporary spasm of small arteries and arterioles, usually in fingers or, rarely, in toes. The cause of Raynaud's disease can be primary and secondary; one of the secondary causes is malignancy. This is a case of a 46 year-old Javanese male with secondary Raynaud's phenomenon associated with colorectal cancer.  
Hubungan Kadar Lemak Viseral dengan Kejadian Obesitas Lansia yang Menderita Diabetes Mellitus Tipe 2 Nugraha, Ida Bagus Aditya; Semaradana, Wayan Giri Putra; Wijayanti, Ni Made Sri; Adnyani, Ni Made Dwi; Laksmi, Ida Ayu Sri Indra; Hendrajaya, Andre; Alvarocky, Rigky; Idris, Prizan Kenny
Muhammadiyah Journal of Geriatric Vol 2, No 1 (2021): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.521 KB) | DOI: 10.24853/mujg.2.1.33-39

Abstract

Latar Belakang: Lemak viseral berkaitan dengan peningkatan risiko kardiovaskular khususnya pada pasien obesitas dengan Diabetes Mellitus tipe 2 (DMT2). Obesitas khususnya obesitas sentral merupakan kondisi penumpukan lemak pada regio perut atau abdominal yang dibuktikan dengan pengukuran indikator lingkar abdomen (atau rasio lingkar abdomen dengan lingkar pinggang). Diabetes sering terkait dengan obesitas dan khususnya pada lansia merupakan populasi yang sangat rentan. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan kadar lemak visceral dengan kejadian obesitas pada lansia DMT2 di Kabupaten Sumbawa Besar. Metode: Metode yang digunakan kasus kontrol, dengan jumlah sampel penelitian berdasar rumus besar sampel sejumlah 41 sampel pasien lansia DMT2 yang berkunjung ke Poliklinik Geriatri RSUD Sumbawa Besar dan RSU Provinsi Manambai, yang memenuhi kriteria inklusi. Analisis data dengan uji Chi Square lalu dengan menghitung rasio odd. Pengolahan data menggunakan program SPSS 16.0 for Windows. Hasil: Didapatkan hubungan yang bermakna antara tingginya kadar lemak viseral dengan kejadian obesitas pada lansia DMT2 dengan p=0.008 (0.05). Pasien DMT2 dengan kadar lemak viseral tinggi memiliki kemungkinan 6.3 kali untuk mengalami obesitas {IK 95% (1.522 - 26.081)}. Simpulan: Terdapat hubungan tingginya kadar lemak viseral dengan obesitas pada lansia dengan DMT2. Perlu diadakan penelitian lanjutan sehingga memberikan efek preventif pada lansia DMT2 dengan obesitas. 
Tantangan Diagnosis Dan Tatalaksana Glucocorticoid Withdrawal Syndrome Dengan Diagnosis Banding Sindrom Cushing: Sebuah Laporan Kasus Pranata, Made Adikosha; Gotera, Wira; Nugraha, Ida Bagus Aditya; Isabella, Karlina; Adnyani, Ni Made Dwi; Wirtayani, Ni Wayan Meindra
Scientific Journal Vol. 4 No. 6 (2025): SCIENA Volume IV No 6, November 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i6.285

Abstract

Glucocorticoid withdrawal syndrome (GWS) presents a significant diagnostic and therapeutic challenge due to overlapping clinical features with Cushing's syndrome. We report the case of a 52-year-old man who presented with severe joint pain, swelling, myalgia, anorexia, nausea, and notable clinical features including moon face, central obesity, and violaceous striae, suggestive of chronic glucocorticoid exposure. His medical history revealed long-term, unsupervised glucocorticoid use through over-the-counter analgesics. Laboratory investigations demonstrated progressive leukocytosis, marked neutrophilia, elevated procalcitonin levels indicative of systemic infection, significant electrolyte disturbances (hyponatremia, hypokalemia), impaired glucose metabolism, and moderate renal dysfunction. Cardiac evaluation revealed atrial fibrillation with rapid ventricular response, congestive heart failure, and left ventricular hypertrophy, consistent with chronic glucocorticoid exposure complications. Initial basal cortisol testing showed normal-low levels, necessitating further confirmation through ACTH stimulation testing to differentiate between glucocorticoid-induced adrenal insufficiency and endogenous hypercortisolism. Management strategies included carefully tapered intravenous glucocorticoids transitioning to oral methylprednisolone, intensive insulin therapy for glycemic control, aggressive treatment of infection, and meticulous fluid-electrolyte management, resulting in clinical and biochemical improvement. The complexity of this case underscores the necessity for a thorough, multidisciplinary approach involving endocrinologists, cardiologists, internists, and nutritionists to ensure optimal management of GWS, prevent adrenal crises, and mitigate long-term cardiovascular and metabolic complications
Co-Authors Alvarocky, Rigky Gede Kambayana Hendrajaya, Andre Ida Bagus Aditya Nugraha Idris, Prizan Kenny Isabella, Karlina Laksmi, Ida Ayu Sri Indra Pranata, Made Adikosha Semaradana, Wayan Giri Putra Wijayanti, Ni Made Sri Wira Gotera Wirtayani, Ni Wayan Meindra