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All Journal Jurnal Teknologi Laboratorium
Özcan, Nurgül
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Second allogeneic stem cell transplantation in acute leukemia patients: single-centre experience Bakırtaş, Mehmet; Yiğenoğlu, Tuğçe Nur; Başcı, Semih; Uncu Ulu, Bahar; Özcan, Nurgül; İskender, Dicle; Dal, Mehmet Sinan; Kızıl Çakar, Merih; Altuntaş, Fevzi
Jurnal Teknologi Laboratorium Vol 9 No 1 (2020): 2020 (1)
Publisher : POLTEKKES KEMENKES YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29238/teknolabjournal.v9i1.208

Abstract

Acute leukaemia patients who relapse after the first allogeneic stem cell transplantation (Allo-SCT) have a poor prognosis. Participating in clinical trials is the best option for these patients. If patients cannot participate in clinical trials, as the treatment options are limited, the second allo-SCT constitutes the potential curative treatment option. The data of acute leukaemia patients who underwent second allo-SCT because of relapsed/refractory disease after the first allo-SCT at our centre between December 2009 and February 2019 were analyzed retrospectively. Three hundred nineteen acute leukaemia patients were performed allo-SCT at our centre. 20 of these 319 acute leukaemia patients relapsed after first allo-SCT and underwent second allo-SCT. 10 AML patients and 10 ALL patients were included in the study. After second allo-SCT overall survival (OS) was 26.1±10.8 weeks, and progression-free survival (PFS) was 19.9±8.6 weeks. If the patients cannot participate in clinical trials, second allo-SCT should be considered for patients with late (≥12 months) relapses after the first allo-SCT. If possible, haploidentical donors should be selected for second allo-SCT and patients should be in complete remission before the transplant.
Co-Authors Altuntaş, Fevzi İskender, Dicle Başcı, Semih Bakırtaş, Mehmet Dal, Mehmet Sinan Kızıl Çakar, Merih Uncu Ulu, Bahar Yiğenoğlu, Tuğçe Nur