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Ä°skender, Dicle
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Journal : Jurnal Teknologi Laboratorium

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Second allogeneic stem cell transplantation in acute leukemia patients: single-centre experience Bakırtaş, Mehmet; Yiğenoğlu, Tuğçe Nur; Başcı, Semih; Uncu Ulu, Bahar; Özcan, Nurgül; İskender, Dicle; Dal, Mehmet Sinan; Kızıl Çakar, Merih; Altuntaş, Fevzi
Jurnal Teknologi Laboratorium Vol 9 No 1 (2020): 2020 (1)
Publisher : POLTEKKES KEMENKES YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29238/teknolabjournal.v9i1.208

Abstract

Acute leukaemia patients who relapse after the first allogeneic stem cell transplantation (Allo-SCT) have a poor prognosis. Participating in clinical trials is the best option for these patients. If patients cannot participate in clinical trials, as the treatment options are limited, the second allo-SCT constitutes the potential curative treatment option. The data of acute leukaemia patients who underwent second allo-SCT because of relapsed/refractory disease after the first allo-SCT at our centre between December 2009 and February 2019 were analyzed retrospectively. Three hundred nineteen acute leukaemia patients were performed allo-SCT at our centre. 20 of these 319 acute leukaemia patients relapsed after first allo-SCT and underwent second allo-SCT. 10 AML patients and 10 ALL patients were included in the study. After second allo-SCT overall survival (OS) was 26.1±10.8 weeks, and progression-free survival (PFS) was 19.9±8.6 weeks. If the patients cannot participate in clinical trials, second allo-SCT should be considered for patients with late (≥12 months) relapses after the first allo-SCT. If possible, haploidentical donors should be selected for second allo-SCT and patients should be in complete remission before the transplant.
Peripheral stem cell mobilization strategies in patients with autologous hematopoietic cell transplantation: A single center's experience NAMDAROĞLU, SİNEM; Yigenoglu, Tugçe Nur; Batgi, Hikmettullah; Uncu Ulu, Bahar; İskender, Dicle; Çakar, Merih; Dal, Mehmet Sinan; Altuntaş, Fevzi
Jurnal Teknologi Laboratorium Vol 9 No 2 (2020): 2020 (2)
Publisher : POLTEKKES KEMENKES YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29238/teknolabjournal.v9i2.247

Abstract

This research is to investigate the parameters which may affect the mobilization of stem cells in patients receiving autologous hematopoietic peripheral blood stem cell transplantation (PBSCT). A retrospective study was carried out using the data derived from the medical files of 242 patients who received PBSCT. Descriptive, clinical, and laboratory parameters were compared between patients with successful and unsuccessful stem cell mobilization. Successful stem cell mobilization ratio was 4.463 times higher when preemptive plerixafor was administrated; 1.032 times higher when CD34+ cell count increased 1 unit at the beginning of mobilization. The white blood cell count was inversely correlated with the success of mobilization. An increase of 1 unit in WBC count was associated with a 1.027 times decrease in the success rate. The data indicated that the administration of preemptive plerixafor and CD34+ cell count at the beginning of mobilization were directly related to the success of mobilization after PBSCT. On contrary, WBC count was inversely associated with the success rate.
Co-Authors Altuntaş, Fevzi Özcan, Nurgül Çakar, Merih Başcı, Semih Bakırtaş, Mehmet Batgi, Hikmettullah Dal, Mehmet Sinan Kızıl Çakar, Merih NAMDAROĞLU, SİNEM Uncu Ulu, Bahar Yiğenoğlu, Tuğçe Nur Yigenoglu, Tugçe Nur