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Jindal, Shammy
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Medicine & Pharmacology

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Traditional and medicinal use of Barbaloin: potential for the management of various diseases Singh, Navdeep; Goyal, Kamya; Sondhi, Shivi; Jindal, Shammy
Journal of Applied Pharmaceutical Research Vol. 8 No. 3 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.3.21.30

Abstract

Barbaloin is the phytoconstituent which is obtained from the plant known as aloe vera.  As we all know aloe vera is the main curative medicinal plants, has been traditionally used as alternative treatment against the many skin diseases. Barbaloin extracted from the aloe vera plant which is physically light yellow colored powder. Extraction of barbaloin from the plant Aloe barbadensis Miller had been accomplished by the Soxhelt extraction, Batch extraction experiment and Ultrasound assisted extraction method (UAE). Barbaloin showed various kinds of therapeutic and medicinal properties like anti-diabetic, antioxidants, anti-cancer, anti-inflammatory and and anti-microbial. It also has good effect on cardiovascular system, test perception, enzyme or metabolism and bioavailability. Our Skin plays an important role in the development of skin diseases because there are many types of skin disorders are developed and the variety of disorders may result to dermatitis or they affect the social wellbeing of a person. Due to their good pharmacological activities, Barbaloin have great potential to treat the different type of skin disorders like Eczema, Psoriasis, Burns and wound, Acne, Dandruff, Frostbite, Rashes, Cold sores, Razor burn and Sunburn. To access the effective use of barbaloin there are various attempts have been experimented on the subject of their Pharmacological activities to check their effect on skin disease and the steps regarding the Isolation of barbaloin also has been made. We can examine their effects on chronic skin diseases. In this review article we discuss about the potential of barbaloin on skin disorders, medicinal importance or Pharmacological activities and their methods of extraction.
A review on characteristics and analytical methods of atovaquone – a potent antimalarial agent Sharma, Sanyam; Sharma, Rahul; Devi, Arti; Jindal, Shammy; Goyal, Kamya
Journal of Applied Pharmaceutical Research Vol. 8 No. 3 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.3.31.37

Abstract

Drugs used in the treatment of malaria that is caused by various plasmosium species i.e. P. falciparum, P. vivax are most irresistible disease throughout the world. The different medications are utilized in the treatment of malaria incorporated the Aryl aminoalcohol mixes: Quinine, Quinidine, Chloroquine, Mefloquine; Antifolate compound: Pyrimethamine, Proguanil, Chlorproguanil, Trimethoprim and Atovaquone. Atovaquone is most effective drug utilized in the treatment of malaria. It must be given in single or in mixture with different antimalarials. An enormous number of methodologies including High Performance Liquid chromatography (HPLC), UV–Visible spectroscopy and Liquid Chromatography-Mass Spectroscopy (LC-MS) are utilized for the determination of atovaquone. Various analytical methods are used for the analysis of pharmaceutical products and these methods were validated according to ICH guidelines (Q1A R2). Thus, this technique can be safely used for the standard quality control analysis of atovaquone.
Development and validation of novel method for simultaneous estimation of Atovaquone and Mefloquine hydrochloride in bulk drug using RP-HPLC Sharma, Sanyam; Ankalgi, Amar Deep; Sharma, Rahul; Devi, Arti; Jindal, Shammy; Goyal, Kamya
Journal of Applied Pharmaceutical Research Vol. 8 No. 3 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.3.48.54

Abstract

Atovaquone and Mefloquine hydrochloride are well known anti-malarial drugs. Literature survey reveals that there was no method available for the selected drug combination. In this way, here an endeavour has been made to develop simple, precise, fast method for simultaneous estimation of atovaquone and mefloquine hydrochloride in bulk drug by using RP-HPLC method. The method was carried out by using gradient HPLC on C18 column using Shimadzu prominence LC 20 AD and mobile phase comprised of Methanol:ACN:Water in the ratio of 85:7.5:7.5 (pH 2.9 was adjusted with OPA). The method was performed with 10µl injection volume. The UV detection was done at 231nm.The retention times of atovaquone and mefloquine hydrochloride were 7.6 and 2.6 min respectively.  The proposed method was validated according to ICH guidelines. The validation parameters were linearity, accuracy, precision (inter-day, intra-day and repeatability) and robustness etc. Linearity was in the range of 80-120µg/ml for atovaquone and 40-60µg/ml for mefloquine hydrochloride. The percent recoveries of both drugs were 99.99-100% and 92.05-99.09%. This method is suitable for the routine analysis of atovaquone and mefloquine hydrochloride in bulk drugs either individually or in mixture
Co-Authors Ankalgi, Amar Deep Devi, Arti Goyal, Kamya Sharma, Rahul Sharma, Sanyam Singh, Navdeep Sondhi, Shivi