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All Journal Makara Journal of Health Research Muslim Education Review
Dinutanayo, Wimba W
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Social Sciences Other

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Intratumor heterogeneity in epithelial cancer: Assessment in cell line models and circulating tumor cells Dinutanayo, Wimba W; Keilholz, Ingeborg T; Braunholz, Diana
Makara Journal of Health Research Vol. 23, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: CTCs are present only in small numbers in patients' blood. This study aimed to establish a protocol for enumeration and phenotypic characterization of circulating tumor cells (CTCs) by ImageStreamX MK II (AMNIS) imaging flow cytometry and to characterize the expression of epithelial, mesenchymal, and stem cell markers in CTCs. Methods: The study used the FaDu cell line at different passages, cisplatin-resistant (FaDu CDDP-R), and irradiation-resistant (FaDu IR-R) subclones, as well as blood samples from head and neck squamous cell carcinoma (HNSCC) and colorectal cancer (CRC) patients for CTC detection (n = 5). Cells were fixed using 4% paraformaldehyde and permeabilized by incubation in 0.3% Triton X-100. The cell suspensions were stained with 1:100 EpCAM AF-488, 1:50 CD45 AF-647, 1:50 Vimentin AF-555, and 1:50 ALDH1A AF-594 antibodies. Results: There were significant differences in EpCAM expression levels between FaDu at late passage and FaDu CDDP-R subclones, as well as between FaDu at late passage compared with FaDu IR-R. Furthermore, CTCs were successfully detected in five patients' samples with various CTC subpopulations. Conclusions: Intratumor heterogeneity in CTC phenotypes existed in CRC and HNSCC. Furthermore, three main subpopulations of CTCs were detected. Our findings strongly support future phenotypic studies of CTCs.
Examining the Roles of Education Civil Society Organizations in Supporting Tertiary Enrollment in Indonesia: A Case Study of the Suryanara Foundation Araminta, Lavinia DW; Dinutanayo, Wimba W
Muslim Education Review Vol. 4 No. 2 (2025)
Publisher : UIII Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56529/mer.v4i2.522

Abstract

This study addresses the low tertiary educational attainment in Indonesia despite the critical role of higher education in societal development. The research aims to assess the contribution of an Indonesian Civil Society Organization (CSO), specifically the Suryanara Foundation, through its mentoring program, Adik Asuh Suryanara, on tertiary enrollment. The study utilizes a case study research design focusing on the organized mentoring program, examining both objective outcomes (tertiary enrollment achievements) and subjective outcomes (participant perceptions). Data collection involved document analysis and a survey conducted among program participants. Results indicate that a significant majority of scholarship awardees successfully enrolled in universities, primarily in state institutions and highly-ranked universities across various disciplines. This achievement is coupled with the perceived personal development of the program participants in terms of the creation of a college-going culture, instrumental and communicative learning, role modeling by mentors, and a sense of community establishment among participants. The study suggests the essential roles of the Suryanara Foundation as an advocate for distributive justice, an agent of empowerment, and a collaborator in supporting tertiary enrollment in Indonesia. By evaluating the effectiveness of the CSO-led mentoring program, this research contributes to the CSO literature towards strengthening the roles of CSOs in enhancing tertiary education access and quality.
Co-Authors Braunholz, Diana Keilholz, Ingeborg T Lavinia DW Araminta, Lavinia DW