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All Journal PCJN Pharmaceutical and Clinical Journal of Nusantara
Syarifudin, Aminah
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Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Analysis of Antalgin (Metamizole Sodium) in Generic Tablet Preparations Using Ultraviolet Spectrophotometry Sulasmi, Sulasmi; Syarifudin, Aminah
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 2 No. 01 (2023): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v2i03.12

Abstract

Antalgin (metamizole sodium) is a non-steroidal anti-inflammatory analgesic widely used in pain management. Quantitative determination of antalgin in pharmaceutical preparations is essential to ensure patient safety and drug quality. This study aimed to determine the maximum absorption wavelength, establish a calibration curve, and quantify antalgin content in generic tablet preparations using ultraviolet (UV) spectrophotometry. Standard solutions were prepared in 0.1 N HCl at concentrations of 8, 12, 16, 20, and 24 μg/mL. The maximum absorption wavelength was determined at 255 nm. The calibration curve yielded a linear regression equation of y = 0.0271x + 0.0031 with a correlation coefficient r = 0.9994, satisfying the acceptance criterion of r ≥ 0.995. Quantitative analysis of six replicate samples yielded a mean antalgin content of 82.78% (range: 77.55–88.00%), which did not meet the Indonesian Pharmacopoeia VI requirement of 95.0–105.0%. The substandard content may be attributed to excipient interference, procedural errors, and improper storage conditions. UV spectrophotometry demonstrated acceptable linearity and precision for antalgin determination.
Evaluation of Anti-Inflammatory Activities of Ethanolic Extract of Curcuma longa Rhizome in Rodent Models Syarifudin, Aminah; Arsita, Cici
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 4 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i03.139

Abstract

Inflammation is a biological response to tissue injury or infection that often requires long-term management. Although synthetic anti-inflammatory drugs are effective, their prolonged use may cause adverse effects, highlighting the need for safer natural alternatives. Curcuma longa L. has been traditionally used for the treatment of inflammatory conditions. This study aimed to evaluate the anti-inflammatory activity of the ethanolic extract of Curcuma longa rhizome using a carrageenan-induced paw edema model in rats. An in vivo experimental study was conducted using male white rats (Rattus norvegicus). The animals were divided into five groups: negative control (0.5% CMC), positive control (diclofenac sodium 10 mg/kg BW), and three treatment groups receiving the ethanolic extract at doses of 100, 200, and 400 mg/kg BW. Paw edema was induced by carrageenan injection, and paw diameter was measured at 0, 2, 4, and 6 hours. Anti-inflammatory activity was expressed as the percentage of inflammation. The ethanolic extract of Curcuma longa significantly reduced inflammation compared to the negative control at all observation times. The 200 mg/kg BW dose exhibited the most effective and consistent anti-inflammatory activity, while a higher dose did not provide additional benefit. The ethanolic extract of Curcuma longa rhizome possesses significant anti-inflammatory activity, with an optimal effect observed at 200 mg/kg BW, supporting its potential as a natural anti-inflammatory agent.
Co-Authors Arsita, Cici Sulasmi Sulasmi