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All Journal Acta Interna : The Journal of Internal Medicine Journal of Placemaking and Streetscape Design
Falah, Khoirul
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Arts Humanities Environmental Science Health Professions Medicine & Pharmacology Social Sciences Transportation

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Positive Anti-Histone Antibodies in Patients with Polymyositis Falah, Khoirul; Mulya, Deshinta Putri
Acta Interna The Journal of Internal Medicine Vol 13, No 1 (2024): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/actainterna.101290

Abstract

Background. Polymyositis is an idiopathic inflammatory myopathy characterized by proximal symmetric muscle weakness, increased skeletal muscle enzyme levels, electromyographic abnormalities, and nonspecific muscle biopsy findings. Autoimmune mechanisms are thought to be the pathogenesis of the disease. Some autoantibodies have specificity and a high relationship with myositis.Case. A 23-year-old male presented with progressive quadriparesis, with predominant lower limb weakness, and severe myalgia of one-month duration, significantly impairing ambulation. He has a history of occupational exposure to propylene gas and atmer liquid while working in a plastic factory. Muscle strength in upper extremities were 4 and lower extremities were 3. Laboratory examination showed CK level 11856 U/L, SGOT 773 U/L, SGPT 486 U/L, LDH 1601 U/L, ANA IF 1:1000 with speckled pattern, normal electroneuromyography, anti-Histone antibodies (++). The patient refused a muscle biopsy. The patient met 2 of the 4 criteria so he was diagnosed with possible polymyositis and was treated with methylprednisolone injection 125 mg/ 6 hours for 3 days then tappering down , mycophenolate acid 2x180 mg , mecobalamin 2x500 mcg, and vitamin D 1x400 mg. After 1 month of therapy, muscle weakness improved and he was able to walk again.Discussion. Specific antibodies for myositis include antisynthetase, anti-Jo-1, anti-PL-7, anti-EJ, anti-PL-12, and anti-Mi-2, antibodies associated with myositis include anti-PM-Sci, anti-Ku , anti-KJ, anti-Ro/SSA.Anti-histone antibodies are commonly present in drug-induced lupus, but some studies have shown an association with other autoimmune and rheumatic diseases. Specificity pattern of serum anti-histone antibodies (AHA) on part of polymyositis patient similar with serum pattern of systemic sclerosis. Another study showed positive results in 17% of 46 polymyositis and dermatomyositis patients.Summary. A young man with clinical and laboratory criteria fulfilling the diagnosis of possible polymyositis, positive anti-histone antibodies were obtained, which is an antibody that is rarely found in cases of polymyositis.
Environmentally-conscious cities: Energy transformation through ecoregional planning and carbon trading for sustainable regional development Falah, Khoirul
Journal of Placemaking and Streetscape Design Vol. 3 No. 1: (July) 2025
Publisher : Institute for Advanced Science Social, and Sustainable Future

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61511/jpstd.v3i1.2025.2168

Abstract

Background: The global climate crisis and dependency on fossil fuels pose serious threats to food, water, and energy security in Indonesia, particularly in ecologically and economically strategic regions such as Garut Regency. This research proposes an integrated strategy for sustainable regional development based on ecoregional planning and carbon trading, addressing spatial inequality, environmental degradation, and clean energy transformation. Methods: Spatial-territorial analysis and participatory cross-sectoral policy review serve as the primary methodology, supplemented by stakeholder interviews and geospatial assessments.  Findings: The findings reveal significant renewable energy potential in Garut, including geothermal (PLTP Darajat), solar, micro-hydro, and biomass from agricultural waste. However, 52.57% land-use misalignment, a 42.46% decline in forest area, and water deficits in 19 sub-districts endanger ecosystem stability and local economic resilience. Strategic ecoregional planning, including environmental carrying capacity-based zoning, 45% protected area retention, and renewable energy integration into spatial plans, can reverse these negative trends. Implementation requires multi-sectoral collaboration involving government, private sector, and communities, supported by green technologies and innovative financing (APBD, KPBU, CSR). The environmental benefits encompass biodiversity conservation, enhanced climate resilience, and emission reductions toward the net-zero emissions 2045 target. Conclusion: This study concludes that Garut’s transformation into an energy-independent, socially equitable, and ecologically resilient region can serve as a national model for achieving the Golden Indonesia 2045 vision. Novelty/Originality of this article: The novelty of this article lies in proposing an integrated ecoregional planning and carbon trading framework as a scalable model for aligning spatial planning, renewable energy development, and socio-political risk management in regional sustainability transitions.
Co-Authors Deshinta Putri Mulya