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Kusuma Astuti, Meira Dewi
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Hubungan Gambaran Histopatologi Dan Derajat Konka Hipertrofi Dengan Sumbatan Hidung Pada Rinosinustis Kronik Kusuma Dewi, Anna Mailasari; Aditomo, Rano; Hariyati, Riece; Kusuma Astuti, Meira Dewi
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.375 KB) | DOI: 10.36408/mhjcm.v7i2.516

Abstract

Latar belakang : Hidung tersumbat dapat disebabkan karena kelainan struktur hidung seperti deviasi septum, atresia koana, konka hipertrofi, celah palatum, hipertrofi adenoid, dan neoplasma. Dua puluh persen populasi dengan hidung tersumbat disebabkan konka hipertrofi. Konka hipertrofi merupakan pembesaran konka akibat bertambahnya ukuran sel konka, yang disebabkan hiperplasia dan hipertrofi lapisan mukosa dan tulang konka. Gambaran hipertrofi dan hiperplasi dapat dilihat melalui pemeriksaan histopatologi. Tujuan penelitian ini untuk mengetahui hubungan gambaran histopatologi dan derajat konka hipertrofi dengan sumbatan hidung pada pasien rinosinusitis kronik (RSK). Metode : Desain penelitian korelasi dengan metode belah lintang pada pasien RSK dengan konka hipertrofi yang menjalani operasi Bedah Sinus Endoskopik Fungsional (BSEF) dan konkotomi. Derajat konka hipertrofi dinilai berdasarkan nasoendoskopi, sedangkan sumbatan hidung menggunakan kuesioner Nasal Obstruction Symptom Evaluation (NOSE). Uji hipotesis yang digunakan adalah uji korelasi Spearman. Hasil : Karakteristik subyek penelitian sebanyak 33 orang, perempuan 60% lebih banyak daripada laki-laki 40%. Derajat sumbatan hidung ringan (30%), sedang (27%), berat (30%) dan sangat berat (13%). Konka hipertrofi terbanyak yaitu derajat 3 (54,5%). Hasil analisis dengan uji korelasi Spearman menunjukkan terdapat korelasi positif dengan nilai korelasi sedang antara derajat konka hipertrofi dengan derajat sumbatan hidung (p=0.02 dan rho = 0.404. Tidak terdapat hubungan yang bermakna antara derajat sumbatan hidung dengan gambaran histopatologi konka inferior (hiperplasia sel goblet, pembentukan kelenjar submukosa, eosinofil, limfosit, neutrofil). Simpulan : Derajat konka hipertrofi berpengaruh terhadap sumbatan hidung. Gambaran histopatologi konka hipertrofi tidak berpengaruh terhadap derajat sumbatan hidung pada pasien RSK. Kata kunci : Rinosinusitis kronik, sumbatan hidung, konka hipertrofi Background: Nasal congestion can be caused by abnormalities of nasal structures such as deviation of the septum, choanal atresia, turbinate hypertrophy, cleft palate, adenoid hypertrophy, and neoplasms. Twenty percent of the population with nasal congestion is due to turbinate hypertrophy. Turbinate hypertrophy is an enlargement of turbinate due to an increase in the size of turbinate cells, which is caused by hyperplasia and hypertrophy of the mucosal layers and turbinate bones. Description of hypertrophy and hyperplasia can be seen through histopathological examination. The purpose of this study was to determine the relationship between histopathological features and the degree of turbinate hypertrophy with nasal obstruction in patients with chronic rhinosinusitis (CRS). Methode: The correlative study design with a cross-sectional method in CSR patients with turbinate hypertrophy who underwent Functional Endoscopic Sinus Surgery (FESS) and turbinectomy. The degree of turbinate hypertrophy was assessed based on nasoendoscopy, whereas nasal obstruction used the Nasal Obstruction Symptom Evaluation (NOSE) questionnaire. The hypothesis test used is the Spearman correlation test. Result: The characteristics of the study subjects were 33 people, more women (60%) than men (40%). The degree of nasal obstruction is mild (30%), moderate (27%), severe (30%) and very severe (13%). Turbinate hypertrophy grade 3 was the most (54,5%). The analyzed using Spearman correlative test showed a positive correlation with a moderate correlation between the degree of turbinate hypertrophy with the degree of nasal obstruction (p=0.02 dan rho = 0.404). There was no significant relationship between the degree of nasal obstruction with histopathological features of the inferior turbinate (goblet cell hyperplasia, the formation of submucosal glands, eosinophils, lymphocytes, and neutrophils). Conclusion: The degree of turbinate hypertrophy affects nasal obstruction. Histopathological features of turbinate hypertrophy do not affect the degree of nasal obstruction in CSR patients. Keyword: Chronic rhinosinusitis, nasal obstruction, turbinate hypertrophy
Ekspresi Reseptor Estrogen, Reseptor Progesteron Dan Digit Ratio Pada Pasien Meningioma Prakoso, Teguh Iman; Arifin, Mohammad Thohar; Sadhana, Udadi; Puspasari, Dik; Kusuma Astuti, Meira Dewi
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.298 KB) | DOI: 10.36408/mhjcm.v7i2.518

Abstract

Latar belakang Meningioma merupakan tumor jinak intrakranial primer yang dipengaruhi oleh keseimbangan hormon estrogen dan progesteron. Digit Ratio (2D : 4D) sangat dipengaruhi oleh paparan hormon androgen prenatal khususnya estrogen dan testosteron. Tujuan Mengetahui hubungan reseptor estrogen (ER) dan reseptor progesteron (PR) dengan Digit Ratio (2D : 4D) pada pasien meningioma. Metode Penelitian observasional analitik dengan desain cross sectional study. Jumlah sampel sebesar 25 pasien meningioma yang dilakukan pemeriksaan ER dan PR. Pengukuran Digit Ratio dilakukan di poliklinik dan bangsal bedah syaraf RSUP Dr. Kariadi Semarang. Uji statistik menggunakan uji spearman. Hasil Digit Ratio kanan, kiri dan selisih kanan-kiri dengan nilai rerata 1,0046; 1,0021 dan 0,0492. Uji spearman, hubungan Digit Ratio kanan, Digit Ratio kiri dan Selisih Digit Ratio kanan kiri dengan PR didapatkan masin–masing nilai p = 0,5 (r = 0,1), p = 0,8 ( r = 0,1), dan p = 0,3 (r = 0,2). Hubungan Digit Ratio kanan, Digit Ratio kiri dan Selisih Digit Ratio kanan kiri dengan ER didapatkan masing–masing nilai p = 0,4 (r = 0,2), p = 0,5 ( r = -0,1), dan p = 0,9 (r = 0,1). Secara statistik terdapat hubungan yang sangat lemah antara Digit Ratio kanan, Digit Ratio kiri, selisih Digit Ratio kanan kiri dengan ER dan PR pada pasien meningioma Simpulan Terdapat hubungan yang sangat lemah antara reseptor estrogen (ER) dan reseptor progesteron (PR) dengan Digit Ratio pada pasien meningioma. Kata kunci : Reseptor Estrogen, Reseptor Progesteron, Digit Ratio, Meningioma. Background Meningiomas are primary intracranial benign tumors that are affected by the balance of estrogen and progesterone. Digit Ratio (2D: 4D) is strongly influenced by exposure to prenatal androgen hormones especially estrogen and testosterone. Objective To determine the relationship between estrogen receptor (ER) and progesterone receptor (PR) with Digit Ratio (2D: 4D) in meningioma patients. Method Analytical observational research with cross-sectional study design. The total sample of 25 meningioma patients who underwent ER and PR examinations. Digit Ratio measurements were performed at the clinic and neurosurgical ward of RSUP Dr. Kariadi Semarang. The Spearman test was used for the statistical test. Results Right, left and right-left difference digit ratio with mean value of 1.0046; 1,0021 and 0,0492. After Spearman test, the relationship between right Digit Ratio, left Digit Ratio and Difference between right and left Digit Ratio with PR was p = 0.5 (r = 0.1), p = 0.8 (r = 0.1), and p = 0.3 (r = 0.2). Correlation between right Digit Ratio, left Digit Ratio and Difference between left and right Digit Ratio with ER was p = 0.4 (r = 0.2), p = 0.5 (r = -0.1), and p = 0.9 (r = 0.1). Statistically there is a very weak relationship between right Digit Ratio, left Digit Ratio, difference between right and left Digit Ratio with ER and PR in patients with meningiomas. Conclusions There is a very weak relationship between estrogen receptors (ER) and progesterone receptors (PR) and Digit Ratio in meningioma patient. Keywords: Estrogen Receptor, Progesterone Receptor, Digit Ratio, Meningioma.
Co-Authors Aditomo, Rano Dik Puspasari, Dik Hariyati, Riece Kusuma Dewi, Anna Mailasari Mohammad Thohar Arifin, Mohammad Thohar Prakoso, Teguh Iman Udadi Sadhana, Udadi