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All Journal Indian Journal of Forensic Medicine & Toxicology
Amjad Gali. Eliwi1, Safaa. Abdul-Hameed. Dadoosh1, Zainab Z. Mohammed Ali1, Abdul Jabar Kalaf Atia1, Iman Rajab Mohammed1, Zaman Ahmed. Hussein1
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Antimicrobial Activity and Characterization of Some Oxazole, Thiazol and Quinoline Amjad Gali. Eliwi1, Safaa. Abdul-Hameed. Dadoosh1, Zainab Z. Mohammed Ali1, Abdul Jabar Kalaf Atia1,
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.2944

Abstract

New Heterocyclic compounds derivatives comprising 1,3-oxazole, chalcone ,thiazole, pyrimidine, quinolone moieties are reported. New derivatives of Quinazolin-4 (3H)-one ring comprising Schiff’s bases,(1,3,4Thiadiazole),(1,3,4-Oxadiazole) and (1,2,4-Triazole), Thiaurease moieties are reported. Compounds (1), (2) and (5) were synthesized by reaction of benzoyl chloride with urea , thiourea and anthranilic acid respectively , then compounds (1)and (2) were converted into(3a-c) and (4a-c) derivatives. While compound (5) reaction with urea to convert to compound (6) which was converted to (7a-c) . chalcone derivatives (9a,b ) were readily obtained by reaction of compound (8) with different aldehydes, Compounds (9a , b) were converted into (10a,b) and (11a,b) The structure of these compounds has been established on the basis of their spectral data FTIR and 1HNMR. These compounds were tested for invitro antibacterial activity against Escherichia coli, Sepidermidis, S.aureusand Klebseillastandard methods. These synthesized compounds have been shown moderate to good antibacterial activity.
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