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All Journal Indian Journal of Forensic Medicine & Toxicology
Saddam Jumaa Nasser1, Muhammed M. Al-Ani2, Mohammad Sinjar Farhan3
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Effect of Metronidazole on Clopidogrel Bisulphate Efficacy in Male Albino Rats Saddam Jumaa Nasser1, Muhammed M. Al-Ani2, Mohammad Sinjar Farhan3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3101

Abstract

The data about this combination effect on platelet function and hematological parameters are sparse, but there is only mention in many medical science websites such as Medscape, there are possible interaction between it, in which metronidazole cause inhibition to cytochrome CYP3A4 which responsible on clopidogrel metabolism, this may put the patients that on clopidogrel bisulphate therapy at risk of clot formation and may be progress, this may occur because clopidogrel is at inactive form and need to activation by cytochrome mention above, so this study was performed in order to achieve the following aims: studying the efficacy of clopidogrel bisulphate on coagulation process by measuring bleeding time when giving clopidogrel alone and in combination with metronidazole and studying the possible effect of two drug alone and in combination on hematological parameters in male albino rats
Deleted Saddam Jumaa Nasser1, Muhammed M. Al-Ani2, Mohammad Sinjar Farhan3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3291

Abstract

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