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All Journal Indian Journal of Forensic Medicine & Toxicology
Rabab Abdulmoez Amin Eltokhy1, Mervat Hamdy Abdelsalam1, Eman Abdelfattah Elzoheiry1, Marwa Issak Mohamed1, Laila Ahmed Rashed2 and Reham Shehab Elnemr3.
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Public Health

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Histopathological Assessment of Hepato-Nephrotoxicity Induced by Nano Copper Particles in Adult Male Albino Rats and the Potential Protective Effect of Alpha Lipoic Acid: A Chronic Study Rabab Abdulmoez Amin Eltokhy1, Mervat Hamdy Abdelsalam1, Eman Abdelfattah Elzoheiry1, Marwa Issak Mo
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3252

Abstract

Background: Copper nanoparticles (CNPs) have unique physical and chemical properties for this reason it was widely used in various medical and non-medical applications. This study aimed to study the toxic effect of copper nanoparticles on liver and kidney through histopathological examination of liver and kidney tissues and if there is improvement of hepato-nephrotoxicity after cessation of exposure and to study the potential protective effect of alpha lipoic acid (ALA) against hepato-nephrotoxicity induced by copper nanoparticles. Finding: Histopathological examination of liver and kidney tissues in rats received CNPs showed significant alteration, cessation of exposure can cause slight improvement and ALA can cause significant improvement. Conclusion: Copper Nanoparticles have hepato-nephrotoxic effect and ALA can be safely used as a protective agent against CNPs toxicity.
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