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All Journal Indian Journal of Forensic Medicine & Toxicology
Anwar A. Abdulla
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Public Health

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Association between Genetic Polymorphism of 5-HTTLPR, and SGOT, SGPT and Catalase with Alcoholism of Iraqi People Anwar A. Abdulla
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3334

Abstract

A case- control study on the relationship of 5-HTTLPR gene polymorphism with alcohol abuse among Iraqi individuals was conducted during period from December 2018 to June 2019. DNA was extracted from the blood samples of the study subjects. The genetic polymorphism analysis was conducted by Restriction Fragment Length Polymorphism (RFLP-PCR) for SLC6A4 gene. The results raveled that the odd ratio for the LL genotype was 1.697 indicating that homo mutant genotype were at higher risk for alcoholism than the wild type SS. This result showed that L allele frequency was (0.78) in alcoholism group and (0.53) in control group whereas S allele frequency was (0.22) in the alcoholism group and (0.47) in the control group. So, the results showed there was a significant difference in allele frequencies of SLC6A4gene between case and control (P<0.01; OR=1.697; 95% CI=0.86-1.64). There was a significant positive correlation between the SGOT activity and the genotype of 5-HTTLPR (SS, SL, LL).Additionally, there was a significantly increased level of liver enzymes (GOT and GPT) and catalase in serum samples of alcoholic males compared with non-alcoholic males.
Deleted Anwar A. Abdulla
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12020

Abstract

a
Association between Genetic Polymorphism of ADH3 exon 8 and ADH2 exon 9 Genes and Specific Enzymes with Alcoholism Anwar A. Abdulla
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14526

Abstract

A retrospective cohort study of the relationship between ADH2- exon9 and ADH3 exon 8 genes polymorphismswith specific enzymes SGOT, SGPT, and catalase among Iraqi individuals identified with alcohol abusewas conducted during period from December 2018 to June 2019. Blood samples of the research subjectshave extracted DNA. The genetic polymorphisms analyses were conducted by Restriction Fragment LengthPolymorphism (RFLP-PCR) for ADH2- exon9 and ADH3 exon 8 genes. The current study shows that thepresence of a catalase was significantly associated with genotype of ADH2- exon9 (AA, AC, CC) amongcases at (p < 0.05). Whereas the presence of an SGOT, SGPT and catalase were non significantly associatedwith genotype of ADH3 exon 8 (AA, AG, GG) among cases at (p < 0.05), while SGPT was significantlyamong control at (p < 0.05).
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