Bladder cancer is the fourth most prevalent tumor in men and eighth in women. Approximately 50,000 new cases are diagnosed annually in the around the world. The study aims at: assess nurse’s knowledge regarding management of patients who undergo the transurethral resection of the bladder tumor. A descriptive study is conducted during the periods of July 29th 2018 to December 25th 2019.The study conducted in Hilla Teaching Hospital and Al’imam Alsadiq Teaching Hospital were the designated site for data collection. By non-probability “purposive sample” of (51) nurses, data were collected for pre-post test and analyzed a descriptive and inferential statistical data analysis approach. Results of the study depicts that age of the nurses ranged from 20- 43 years, (60%) of nurses in the control group, there were somewhat less female nurses (45.2%) than male nurses (54.8%) in the study group and (32%) were female and (68%) nurses male in the control group, (80.6%were married in the study group and 22 (88%) were married in the control group, education was from a secondary nursing school and institute degree (35.5%) for each degree in the study group, and (48%) institute degree in the control group, (1-5) years was (67.7%) in the study group and (68%) in the control group. Nurses knowledge in the study group has increased from (M.S. 1.3026) in the pretest time to (M.S. 1.6787) in post test time for the control group, this score has slightly increase from pre test (M.S. 1.2985) to post tests (M.S. 1.3343). There were concluded improving in nurses’ knowledge after post-test for study group for educational program concerning management of patients with transurethral resection of the bladder tumor. While control group did not present any improvement in their knowledge concerning management of patients with transurethral resection of the bladder tumor at pre and post-test. It is need to be encouraging nurses to be enrolled in training sessions to improve their knowledge to keep them up to date toward management of patients with transurethral resection of the bladder tumor.