Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Indian Journal of Forensic Medicine & Toxicology
Ali K. Dahir1 , Alaa S. Al-Awad2 , Moaed E. Al-Gazally3
Unknown Affiliation
Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Investigation the Association of the VEGFR-2 and -2578C\A Polymorphism as a Risk Factor for Incidence of Lung Cancer in Babylon Province Ali K. Dahir1 , Alaa S. Al-Awad2 , Moaed E. Al-Gazally3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10794

Abstract

Background: VEGF gene polymorphisms can induce either increase or inhibition of VEGF secretion, with altered promoter activity. Aim: We investigated the association of the VEGFR-2 and -2578C\A polymorphism in the VEGF gene with Lung cancer risk in Babylon province. Methodology: VEGFR-2 level was measured by Enzyme Linked Immunoabsorbant Assay ELISA and Genotyping of the VEGF-gene variation (-2578A\C) was performed using the amplification refractory mutation system PCR. We investigated the association of VEGF gene variants with different clinicopathological features of lung cancer patients. Results: No significant difference was seen of the VEGFR-2 levels in lung cancer patients when compared with control group (P=092), the allelic frequency of -2578 A\C VEGF gene no difference was seen in patients lung cancer (p=0.652). Hardy-Weinberg equilibrium showed a significant difference cases group (p=0.016), also revealed A allele exhibits a pathological behavior and it appears in over-dominant model (p=0.05), this proves that there is significant association of -2578A\C VEGF gene in lung cancer patients. Conclusion: Our results showed no significant association of the VEGFR-2 in lung cancer patients while showed a significant association of the VEGF -2578C\A polymorphism with LC susceptibility in Babylon province .The VEGF -2578C\A heterozygote significantly increases the risk and can be useful as a predisposing genetic marker.
Co-Authors