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All Journal Indian Journal of Forensic Medicine & Toxicology
Ali Z. Al-Saffar1 , Noora A. Hadi2 , Hadeel Mohamed Khalaf3
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Antitumor Activity of ?-glucan Extracted from Pleurotus Eryngii Ali Z. Al-Saffar1 , Noora A. Hadi2 , Hadeel Mohamed Khalaf3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10811

Abstract

Pleurotus eryngii, a type of edible mushroom that exhibit various pharmacological properties, including antioxidant and anticancer effects. In the present study, extracted ?-glucan from the P. eryngii was tested as an antioxidant and anti-tumor factor. ?-glucan was extracted and analyzed by HPLC and FT-IR. Analytical results showed more than 90% similarity in chemical structure and purity. Potential antioxidant activity of ?-glucan was examined using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and compared with ascorbic acid.?- glucan confirmed a potential scavenging activity. The anticancer activity of the?-glucan was assessed using different concentrations (6.25 to 400 µgmL-1) on MCF-7 and HepG2 cell lines. P. eryngii?-glucan exerted a dose-dependent reduction in MCF-7 and HepG2 cell viability with an IC50 of 280.00 and 539.5 µg mL-1, respectively. At the same time, no significant effect was recorded on normal cell line WRL 68. The obtained results are expected that could be used to develop P. eryngii?-glucanas an antitumor drug
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