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All Journal Indian Journal of Forensic Medicine & Toxicology
Ahlam A. AL-Rikaby1, Mitham A. AL-Rikaby2 , Saleh K.Majeed3, Researcher/Hussein S. AL-Jaberi1
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Influence of Sesame Oil on Physiologic and Histopathological Changes in Alloxnized Male Guinea Pigs Ahlam A. AL-Rikaby1, Mitham A. AL-Rikaby2 , Saleh K.Majeed3, Researcher/Hussein S. AL-Jaberi1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.11759

Abstract

The current study was to investigate the effect sesame oil (Sesamum indicum L) on glycosylated hemoglobin,blood glucose, Malondialdehyde, semen and hormonal parameters, in addition the histopathologicalchanges on pancreas in diabetic pigs. The physiological indices were examined in control, diabetic and oiltreated diabetic pigs. Eighteen male pigs were randomly assigned into three groups, group one as control,group two diabetic as positive control and group three diabetic treatment with sesame oil at dose (1ml/kg)orally, after 30 days whole blood samples were collected to measure the hemoglobin A1c and other sampleswere separated into serum for blood glucose and MDA and hormonal assays. Epididymal taken for spermparameters examined, all animals were sacrificed and pancreas was taken for histological study. Outcomesof this study indicate that significantly reduction in serum Malondialdehyde level in associated with loweredlevels of blood glucose and hemoglobin A1c, While, significantly elevation in serum testosterone, FSHand LH levels accompanied with the improved spermatogenesis were observed in group treated with thesesame oil. In addition, the a significant islet langer hans restoration was notable. Conclusion: The oil hasantioxidant and ameliorated effects on pancreatic function and markedly improved sperm profile.
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