<![CDATA[Background: Breast cancer is the commonest malignancy of females all over the world and the secondleading cause of death due to malignancy among females. Breast cancer is regarded as a unique disease inoncology and the specific markers such as ER, PR, HER-2/neu and others are used to predict the prognosisand the treatment response to guide the therapeutic plan.Aim of the Study: To clarify if there is any significant difference in the intrinsic molecular profile of breastcancer in old age patients in comparison to young age patients.Material & Methods: Samples of primary carcinoma of breast, obtained from 211 female patients withbreast cancer. The patients are divided into two group. Immunohistochemical analysis was done for thespecimens by using Envision method for detection of estrogen receptor, progesterone receptor, Her2/neu.Statistical analysis was done by using SPSS. In which we use frequency, percentage and mean as descriptivestatistics while chi square and Yates corrected chi square as analytic statistics.Result: We found molecular intrinsic breast cancer subtypes have a significant difference in distributionof elderly breast cancer compared to their younger counterparts where elderly patients more frequentlyLuminal A and Luminal B tumor subtypes and less frequently HER2+ and basal molecular subtypes.Conclusion old age breast cancer patients have better prognosis in comparison to young age patientsaccording to the biological profile, histopathological type and Immunohistochemical prognostic parameters.]]>
