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All Journal Indian Journal of Forensic Medicine & Toxicology
Talib Waseen Hussein1 , Waheeda Rasheed Ali1, Haider F. Ghazi2
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Public Health

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Immunohistochemical Evaluation of Apoptotic Proteins Expression in Liver and Spleen after Treatment of Cystic Echinococcosis: An Experimental Study Talib Waseen Hussein1 , Waheeda Rasheed Ali1, Haider F. Ghazi2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.11804

Abstract

The cellular immune response and apoptotic pathways are closely related dose dependent responses againstEchinococcus granulosus antigens. The aim of this study is to evaluate the cellular expression of Bax,Bcl-2 and Caspase-3 in both liver and spleen of experimentally cystic echinococcosis mice treated withOxfendazole, Oxfendazole +Praziquantel, Oxfendazole +Albendazole and Albendazole +Praziquantel ofexperimentally mice model of cystic echinococcosis. After 2 months of treatment, mice were sacrificed andboth liver and spleen were processed for immunohistochemistry staining protocol using specific primaryantibody against mouse Bax, Bcl-2 and Caspase-3 proteins. The results showed that E. granulosus infectionable to induce apoptosis in both liver and spleen tissues after induction of cystic echinococcosis mice model,treatment with Albendazole in combination form gives better results because of attenuation of apoptosispathway and restore of normal cellular behavior. In conclusion, this study describes the involvement ofapoptosis in the pathogenesis of cystic echinococcosis.
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