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All Journal Indian Journal of Forensic Medicine & Toxicology
Manal M. Kadhim1 , Ali S. Shakir2
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CD14 C(-260)T Polymorphism and Blood Levels of the Soluble Endotoxin Receptor CD14, their Association with Risk of Ischemic Stroke in Iraqi Populations Manal M. Kadhim1 , Ali S. Shakir2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.11838

Abstract

Background: Stroke is a main cause of death and adult long-term disability worldwide, and stays as anenormous burden for society due to lack of illustrated etiology and effective treatments. Aim: the presentstudy was conducted to investigate the association of CD14 genotype and plasma levels of soluble(s) CD14with risk of ischemic stroke. Methods : A total of 40 patients with ischemic stroke were included in the studywho were admitted to hospital from the period between March to August 2019, and other groups consistof 40 apparently healthy individuals. A five ml of blood samples were collected, 2 ml of each sample forpolymerase chain reaction amplification and detection of CD14 technique. The remaining (3ml) for CD14monocyte count by Flow cytometry technique. Results: CD14 C(-260)T genotype was not significantlyassociated with increased risk of IS (P= 0.367). However, sCD14 plasma levels were higher in subjects withTT genotype compared with those with CT or CC genotype (P= 0.013). The count of CD14 Monocytes,in Ischemic Stroke patients was significantly higher than that of healthy control group. Conclusion: asignificant correlation between CD14 genotype and sCD14 levels were higher level in subjects with TTgenotype compared with those with CT or CC genotype.
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