<![CDATA[Background : Visual inspection by conventional oral examination (COE) has been the backbone of oralcancer and precancer detection. More recently, several commercially available diagnostic adjuncts havebeen developed to aid clinicians in the early detection of oral epithelial dysplasia (OED) and squamous cellcarcinoma (SCC), such as OralCDx, Toluidine coloring, ViziLite machine, Identafi machine, and VELscope.VELscope is a technology based on the principles of autofluorescence mechanism imaging. This deviceoffers in-vivo, real-time, direct visualization of tissue autofluorescence, termed direct visual fluorescentexamination (DVFE). It is currently marketed as an oral cancer screening tool to be used with all new andrecall dental patients and as an aid for surgeons in tumor margin delineation.Aim of the study :was to obtain auto fluorescent data on variety of histopathologically distinct oral lesionsand assessment of direct auto fluorescent examination validity in identifying dysplastic (premalignant)and malignant oral mucosal lesions using VELscope and judgment with histopathological examination.Materials and methods: Routine oral examination of fifty patients having suspicious oral lesions followedby direct autofluorescent examination by VElscope and then histopathological examination.Conclusion : VELscope can be considered as an adjunctive device to enhance the visualization of oralmucosal abnormalities, but not as a tool for risk stratification.]]>
