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All Journal Indian Journal of Forensic Medicine & Toxicology
Hindreen Saleh Mohammed1 , Hayder B Sahib2
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The Anti-Proliferative Activity of Ephedra Aphylla Methanol Extract Against Liver Cancer Cell Line Hindreen Saleh Mohammed1 , Hayder B Sahib2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12056

Abstract

This study aimed to investigate the anti-proliferation activities of methanol extract ephedra aphylla against(HC) liver cancer cell line in vitro and to identify the possible mechanism of action. Anti-proliferativeactivity of the plant extracts against the cancerous cell lines was tested by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on liver cancer cell line (HC). Gene expression studies usingqPCR for the proapoptotic gene P53 were also carried out. The methanol extract of ephedra aphylla exhibitedpromising anti-proliferative activity. Dose response relationship was shown after 72hr incubation. Significantcytotoxic activity of methanol extracts has identified on HC, IC50 was (6.79 ?g/ml). Furthermore, methanolextract significantly up-regulated the expression of P53. Thus, these findings suggest potential utilization ofephedra aphylla as new source in researching for new anticancer agents.
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