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All Journal Indian Journal of Forensic Medicine & Toxicology
Sayed A. M. Amer1,2, Abdulaziz S. Asiri3 , Ziad F. Al-Shalaan4 , Ahmed Ch. Kassab1 , Ahmed M. Refaat5
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Forensic Application of ATP6 Gene Haplogroups in a Cohort of Obese Saudis Sayed A. M. Amer1,2, Abdulaziz S. Asiri3 , Ziad F. Al-Shalaan4 , Ahmed Ch. Kassab1 , Ahmed M. Refaat
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12160

Abstract

Blood samples from 108 obese individuals (73 males and 35 females) and 106 healthy ones (79 males and27 females) were collected from a cohort of Saudis inhabiting Riyadh province. ATP6 mitochondrial genewas amplified and sequenced to identify obesity-related SNPs and the mitochondrial DNA haplogroups forforensic purposes. A novel site (A8660G) was found while C8655T and T9103C were obesity- related sites.The haplogroups H2a and H1a were common as they were found in 70.4% and 66% of obese and non-obeseindividuals, respectively. L2 was recorded in the obese samples only and H21 was recorded in the obesemales only. The J2a haplohroup was more common in obese individuals. Constructing mtDNA database forpeople inhabiting different regions of Saudi Arabia for forensic purpose and to affirm the utility of H21 andL2 in identifiying obesity is necessary.
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