Background: Communicable diseases are those that spread by an infectious agent, such as bacteria, viruses,fungi or parasites. Leprosy was once feared as a highly contagious and devastating disease, but it doesn’tspread easily and treatment is very effective.1 However, if left untreated, the nerve damage can result incrippling of hands and feet, paralysis, and blindness. Leprosy and Tuberculosis, is been a threatening issue allover the world. It’s been hugely spreading, since it caused by air-borne organisms and is highly contagious.It’s been observed that 1/3rd population of the world have latent tuberculosis, which simply means, if nottaken care, they can develop higher stages and get ill. 2There is a strong need to identify the cases at earlystages so that mortality and morbidity can be preventedAim and Objective: This study aims to identify the suspects cases of leprosy and tuberculosis based ontentative sign and symptoms and its association with the gender so that early detection can be done to reducethe mortality and morbidity rates.Research Methodology: The quantitative approach is used for the Study. A descriptive survey design isadopted on 300 samples which are chosen by the convenience sampling method. An assessment protocol hasbeen prepared to assess the sign and symptoms of leprosy and Tuberculosis. The suspect cases then referredto the Urban Primary Health centres for the confirmation of the diagnosis so that treatment can be initiatedat the earliest.Results and conclusion : The study results showed,almost 13 to 15 suspects found in the Urban slum withthe surveyed population of 300. The associated factors with selected demographic variables were lesion andeye pain in leprosy cases and cough in Tuberculosis Cases .The suspect cases are referred to UPH where 13cases of Leprosy and 14 cases of Tuberculosis were confirmed. It is recommended that the associated factorsneed to be explored further to rule out the other factors relate to incidence of diseases.