Sickle-cell disease (SCD)) is a group of genetic disorders that is characterized by the development ofabnormal hemoglobin (Hgb S), abnormal red blood cells, and the resultant complications include vasoocclusive pain crises, acute chest syndrome, acute splenic sequestration& pneumococcal disease.Objectives of the study: To assess the self efficacy of patients with sickle – cell anemia at blood diseaseward in Baghdad Teaching hospital and to find out the association of some demographical characteristicsof the sample such as ( age , gender, level of education & years of disease affected) with self efficacy.Methodology: A descriptive design of study was carried out, for the period 1st Oct, 2017 – 15th of May,2018, to identify the self – efficacy of sickle cell patients, A 40 patients was participate at the study. Thesetting was Baghdad Teaching Hospital, Ghazi –Al Hariri Teaching Hospital IBN-Al Belady teachinghospital. Results: Most of study participants are females (60.0%) , More than a third are within the agegroup of (22-25) years-old (35.0%),they were at high school graduate (27.0%), followed by those who aremiddle school graduates (25.0%), those who are both elementary school graduate and hold a bachelor’sdegree (15.0%), and those who are unable to read and write (7.5%). More than a half are married (55.0%),followed by those who are married (30.0%), those who are divorced (12.5%). Less than a third are students(n = 12; 30.0%), followed by those who are self-employed (27.5%), those who are out of work (20.0%),those who are officers (12.5%), and those who are housewives .Less than a half reported that their fatheris the affected person (45.0%), followed by mothers (27.5%), relatives (15.0%), and both parents (12.5%).Regarding health status, the health of the majority are fair (80.0%), followed by those who have poorhealth (n = 6; 15.0%), and those who have good health (5.0%). More than two-fifth reported that they arehospitalized (4-6) times per year. All patients reported that they have been treated for more than 10 years(100.0%). Conclusions: findings of study shows that ,male participants have a better self-efficacy of activityof daily living than female participants of activity of daily living, level of education, age, family ranking &financial social status.