Desquamative gingivitis is an elucidating term used to demonstrate epithelial desquamation erythema,erosions and vesiculobullous lesions. It is a clinical manifestation that can be caused by several systemicdisorders. Detection and differentiation between conditions that manifest desquamative gingivitis hasbeen a continuing problem. Accurate clinical, histologic and serologic investigations are often required todifferentiate among desquamative gingivitis disorder. This study focuses on understanding the correlationbetween clinically desquamative gingivitis and the histopathological reports. A retrospective cross-sectionalstudy was conducted using the patient records from the department of periodontics and oral pathology,Saveetha Dental College from June 2019- April 2020 and patients who underwent treatment for desquamativegingivitis were selected by nonprobability sampling Microsoft Excel® 2016 (Microsoft office 10) dataspreadsheet was used to collect data and later exported to SPSS® statistical package for social sciencesfor Windows ( version 20.0, SPSS Inc, Chicago IU, USA). From the data analyzed it is observed that theoverall incidence of desquamative gingivitis was higher in females (60%) predominantly in the age group of(51-60) years (50%). The most predominant histopathology report diagnosed Oral lichen Planus (70%). Thecorrelation between clinical diagnosis and histopathology reports was statistically significant with p<0.05.Within the limits of the study, a significant number of patients with desquamative gingivitis had a femalepredilection predominantly in the age group of 50-60 years. The most common histopathology report ofclinically desquamative gingivitis was Oral Lichen Planus. As clinically suggestive desquamative gingivitismay be an initial symptom of a systemic disease, the need for biopsy as a diagnostic tool should be mademandatory