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All Journal Indian Journal of Forensic Medicine & Toxicology
Nishanthana Murali1 , Vijayashree Priyadharsini J2 , Anitha Roy3
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Oncogenes Associated with Oral Cancer - An Update Nishanthana Murali1 , Vijayashree Priyadharsini J2 , Anitha Roy3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12404

Abstract

Oral cancer and oropharyngeal cancer represent a large group disorder that falls into the head and neckcategory and is considered as the most leading cause of death in developing countries. The prime reasonfor the high mortality rate of patients suffering from oral cancer is the delay in the diagnosis of the type andgrade of oral cancer and also in the offering of prompt treatment. A report from India demonstrated that 35%of oral squamous carcinoma contains H-ras gene mutations which are an oncogene. Advances in the field ofoncogenes have created an instrument to examine the various phases of carcinogenesis, including progressfrom premalignant to metastatic stages. These systems have direct importance to oral malignancy wherethe precancerous stage is very much characterized. Primer investigations into the articulation and capacityof oncogenes recommend anomalies including the individual proliferation of at least three kinds of theseoncogenes. Some of the oncogenes associated with oral cancer are studied in this article and the factorscontributing to its molecular basis like chromosome instability and telomerase activity are also discussedbriefly. There are many risk factors and other predisposing factors that may affect the diagnosis, prognosis,and progression of oral cancer and are also discussed in this article.
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