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All Journal Indian Journal of Forensic Medicine & Toxicology
K.M. Hiwale1 , Harshala Lokhande2 , Sunita Vagha3
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Gastrointestinal Stromal Tumourmetastasis in Lymph Node: A Case Report K.M. Hiwale1 , Harshala Lokhande2 , Sunita Vagha3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12670

Abstract

Background: GIST are the tumours originating in the gastrointestinal tract with a high malignant potentialand the chance to metastasize and recur. They are widely studied due to their distinctive biologic behavior,clinicopathological manifestations, molecular mechanisms and treatment modalities. They can affect anypart of gastrointestinal tract or extraintestinal sites. Most GISTs stain positive for KIT, CD117 andanoctamin1(DOG-1). Tumorresection along with Imatinib therapy is said to be mainstay of the treatment.Case Presentation: Here by presenting a case of a male aged 60 years operated for cholecystectomy andintraoperatively found to have a solitary nodule over the stomach, which was later found out to be GISTmetastasis to a lymph node on histopathology.Conclusion: GIST has a low incidence and rare tendency to metastasize to lymph node; therefore it isimportant to study clinical importance to lymph node in this malignancy. Lymph node dissection shouldtherefore be kept in mind during resection of GIST.
Rhinoscleroma: A Case Report K.M. Hiwale1 , Harshala Lokhande2 , Sunita Vagha3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12671

Abstract

Background: Rhinoscleroma is a chronic granulomatous disease caused by gram negative bacteria;Klebsiellarhinoscleromatis. Respiratory mucosa is predominantly affected involving mainly the nasal cavityand nasopharynx and further extending to the respiratory tract. Systemic involvement is rare. The bacilli canbe stained for histopathological examination by Hand E, Gram’s stain and Giemsa stain. Treatment beingantibiotics and anti-inflammatory drugs.Case Presentation: Hereby presenting a case of 52 year old male with nasal blockage; clinically found tohave a mass encasing the bilateral chonchae and nasopharyngeal wall being investigated for malignancy, butproved to be diagnosed with rhinoscleroma on histopathology.Conclusion: Rhinoscleroma, usually difficult to diagnose, may be confused with granulomatous disease,carcinoma, tuberculosis and leprosy. Seen majorly affecting the respiratory tract, adequate biopsy materialsent for histopathology may prove to be useful in the diagnosis; along with a proper clinical history. Thepresence of inflammatory background containing Mikulicz cells are highly suspicious of rhinoscleroma. Thedisease often presents with nasal mass therefore clinically mimics with neoplastic mass. Due to its chroniccourse, it often proves challenging to treat. Early diagnosis thus ensures timely treatment further avoidingrelapses and complications.
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