Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Indian Journal of Forensic Medicine & Toxicology
Duaa Ghazi1 , Hasan Faisal Kahya2
Unknown Affiliation
Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Purified Pyocyanin from Clinical Isolates of Pseudomonas aeruginosa Enhances Antibiotic Sensitivity Against Some Pathogenic Bacteria Duaa Ghazi1 , Hasan Faisal Kahya2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13546

Abstract

Pseudomonas aeruginosa is one of the most life-threatening pathogen. It is considered nosocomialopportunistic microbe that cause wide range of infections including wound and burn infections, respiratoryinfections, and Otitis media. Despite the efficiency of antibiotics against infectious diseases, P. aeruginosastill causes complicated infections with antibiotic resistance in many clinical strains. The pigments producedby P. aeruginosa exhibits antibacterial properties. Thus, we have examined its ability to enhance antibioticseffect against some pathogenic microbes. 286 samples were collected from patients with different infectionswho visited Mosul hospitals. 76 samples were positive to P.aeruginosa. Among them, 38 (13.28%) of isolateswere isolated from surgical infection, whereas, 12 (4.19%), 11(3.84%), and 7(2.447%) were isolated fromOtitis media, Urinary tract infection, and pus, respectively. The pyocyanin in low concentrations showedsynergistic effect with some antibiotics against Staphylococcus aureus and Escherichia coli. E. coli becamesensitive to ciprofloxacin and nalidixic acid when mixed with 100 mg/ml pyocyanin. However, cloxacillindid not show any activity against Staph.aureus when mixed with 1 mg/ml and 6.25 mg/ml pyocyanin. Staphaureus became sensitive to nalidixic acid when mixed with 1 mg/ml pyocyanin.
Co-Authors