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All Journal Indian Journal of Forensic Medicine & Toxicology
Shaimaa A. Al-Oubaidy1 , Asmaa Mohammed Mekkey2 , Ahmed Zuhair Alwaeli3
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Genetic Modification of Mitochondrial DNA in Cancer Cells Shaimaa A. Al-Oubaidy1 , Asmaa Mohammed Mekkey2 , Ahmed Zuhair Alwaeli3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13630

Abstract

Mitochondria is one of the most energy source in the cells, in addition to DNA encoded to several geneswhich relatively associated with several disease, researchers proved the role of mitochondrial in energydemand to tumor cells in addition to mitochondrial DNA role in cancer initiation and development. Thepresent review explained different objectives related with the mitochondrial role in tumor incidence ;these included Tumor cells energy demands, Mitochondrial Mutations redundancy and allocation, Geneticdisparate natural Selection in Tumor initiation, Mitochondrial Modifications Clinical Translations in Cancer,Association Mitochondria, epigenetics and Cancer and finally Injury of Mitochondria in Cancer. The presentreview concluded that the most important role of mitochondrial as cells an organelles for energy suppliersto tumor cells metastasis and immorality also the mutations of mtDNA and their role in carcinogenesis werewell proved in different cancer types.
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