Insufficient information regarding Alzheimer’s disease (AD) among the healthcare workers can harmfullyaffect outcomes of the patient. This designate the necessity for constant knowledge supplement on ADamong them in order to deliver the best care to AD patients as possible and propose the necessity to evaluatethe level of AD understanding among nurses and identify their shortages so as to improve care quality andpromote life quality for individuals with AD. Aims of the study: Current study designed to (i) evaluate theknowledge concerning AD among the nurses working in the hospitals of Thi-Qar governorate/Iraq, and(ii) measure the relationship between selected nurses’ demographics and their knowledge on AD. A surveydesign was applied to assess the nurses’ knowledge regarding AD.(i) Self-designed questionnaire was used to collect Socio-demographic characteristics of the participantswhich included of 7 items (age, gender, years of experience, educational level, department of work, previoustraining, and previous caregiving experience).(ii) Alzheimer’s Disease Knowledge Scale (ADKS) were used to assess nurses’ knowledge regardingAD. This study was conducted in four Teaching Hospitals in Thi-Qar governorate /Iraq. A 622 nurseswere participated in the study. The results involved answers from 622 nurses. Nurses knowledge was inaverage (Mean=15.93). Also, there were a statistically significant relationship between certain demographiccharacteristics (Age, previous training, and previous caregiving experience) and knowledge of the nursesconcerning AD. This study exhibited many findings on this important subject, in addition to the demographiccharacteristics and its relation to nurses’ knowledge.