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All Journal Indian Journal of Forensic Medicine & Toxicology
Zinah Saad Madhloom1 , Aqeel Shakir Mahmood2 , Alice Krikor Melconian3
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The Effect of Biomarker (IL-8) on the Tissue of Colorectal Cancer Patients by using IHC Technique Zinah Saad Madhloom1 , Aqeel Shakir Mahmood2 , Alice Krikor Melconian3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13764

Abstract

Aim: The search to evidence a link between the molecular markers (IL-8) with colorectal cancer. The aimof the presented work is examining the relation regarding the biomarker (IL-8) in colorectal cancer (CRC)tissues as well as its relation with the other clinic pathological variables.Methods: The detection of IL-8was confirmed using histopathological examination of colonic biopsy oftissue section fixed on slides previously coated and analyzed by immunohistochemistry method (IHC),hence to detect the variable regarding IL-8 expression in normal as well as CRC tissues including (adjacentnormal tissue and healthy controls tissues); in addition to its association with other clinic-pathologicalvariables (intensity, gender and age).The results of the study specified the enrichment regarding IL-8 expression in the samples of CRC with theuse of IHC approach. No considerable relation has been indicated between the expression of IL-8 with theother clinical-pathological variables (gender and age), yet there has been considerable relation between theexpression of IL-8 and the stain’s intensity (grade), while it has been increased in tissues of CRC; this mightbe specified as one of the risk factors with regard to the CRC’s development and the metastasis in the samplesof CRC, also it might be significant marker to predict insignificant prognosis in patients experiencing CRC,also it can be utilized as possible therapeutic target in the CRC.
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