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All Journal Journal of Agromedicine and Medical Sciences OISAA Journal of Indonesia Emas
Muhammad Yuda Nugraha
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Humanities Education Engineering Health Professions Law, Crime, Criminology & Criminal Justice Social Sciences

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ENHANCING THE POTENCIES OF CHIMERIC ANTIGEN RECEPTOR T CELL (CAR T CELL) BY CRISPR/CAS9 SYSTEM TO ERADICATE RETINOBLASTOMA Yehuda Tri Nugroho Supranoto; Muhammad Yuda Nugraha; Astuti Setyawardani
Jurnal PPI Dunia Vol 3 No 2 (2020)
Publisher : OISAA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52162/jie.2020.003.02.5

Abstract

Retinoblastoma (RB) is the most common primary intraocular malignancy of childhood. There is no therapies that can eradicate specifically the whole cancer cells without any side effects. The disialoganglioside 2 (GD2), one of the cancer’s cell markers that can be treated using immunotherapy, is expressed in RB. Through this fact, immunotherapy based on chimeric antigen receptor (CAR)-engineered T cells targeting cancer-specific antigens has shown great potential in treating this cancer. Although in recent studies show that immune cells are not able to destroy cancer cells because in every cancer cells there is protein programmed death ligand 1 (PD-L1). This literature review also shows the potential technology using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated protein (Cas9) method to silence PD-1 in CAR T cell, so PD-L1 can not deactivate CAR T Cell through PD-1 signaling. The combination using CAR T cell and CRISPR-Cas9 will be the great therapy to eradicate RB without any side effect.
An Extension Form of Chiari 1 malformation: A Case Report Wiryaning Putri, Komang Yunita; Novan Krisno Adji; Ulfa Elfiah; Muhammad Yuda Nugraha
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53709

Abstract

The updated classification of Chiari malformation includes Chiari 1.5 malformation, which explicitly denotes the tonsillar herniation characteristic of Chiari 1 malformation, accompanied by an extended brainstem and a dilated fourth ventricle. We present a Chiari 1 malformation characterized by significant downward herniation of the tonsils and the development of syringomyelia, with no indication of elongation of the fourth ventricle. This example represents an extension of Chiari 1 malformation, which is currently not classified as Chiari 1.5 malformation. A 27-year-old female exhibited cephalic and cervical discomfort for two years. The initial MRI indicated a fall of the cerebellar tonsil beneath the foramen magnum. The midsagittal MRI assessed the degree of tonsillar herniation beneath the foramen magnum. Tonsillar herniation was observed at the C2 level; a spinal MRI revealed syringomyelia affecting the C2 to C3 levels. The patient received a suboccipital craniectomy and C1-C2 laminectomy. There was dural sac pulsation at the C2 level. The patient's cervical discomfort resolved entirely following the surgical procedure. This case represents an extension of Chiari 1 malformation, which is currently not classified as adenotes explicitly 1.5 malformation. 
Co-Authors Astuti Setyawardani Novan Krisno Adji Ulfa Elfiah Wiryaning Putri, Komang Yunita Yehuda Tri Nugroho Supranoto