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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences
Deocaris, Custer C
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Agriculture, Biological Sciences & Forestry Environmental Science

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Maternal Diet During Pregnancy and COVID-19 Susceptibility of Offspring: The “Thrifty Phenotype Hypothesis” Connection Deocaris, Custer C; Alinsug, Malona V
Journal of Tropical Life Science Vol 11, No 1 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.01.07

Abstract

There is accumulating evidence suggesting that ACE2, the host cell receptor for the spike (S) protein of the SARS-CoV-2, mediates viral entry and infection, is under epigenetic control. Here, we discuss studies suggesting a nutritional strategy for down-regulating ACE2 expression in tissues of offspring through the phenomenon of maternal epigenomic reprogramming mediated by maternal diet. The "thrifty hypothesis" was first proposed by Hales and Barker, which posits that specific genes are programmed based on early-life experience to promote efficient fat deposition and storage in adulthood. Our analysis of the proposed mechanism for "early life programming" in this paper via nutritional modulation of histone acetylation and DNA methylation goes beyond the physiological consequence of boosting the innate cellular resistance to a viral transmission. During the pandemic, where there is still no specific antiviral drug or a widely disseminated vaccine for COVID-19, we hypothesize that an epigenomic nutrition approach may be a practical approach to help mitigate viral transmission offspring.
Potential and Performance of Accelerated Solvent Extraction (ASE) in Obtaining Bioactive Compounds from Bee Propolis as Compared with Other Extraction Methods Mojica, Elmer-Rico E.; Charland, Jozlyn M; Deocaris, Custer C; Micor, Jose Rene L
Journal of Tropical Life Science Vol 11, No 2 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.02.08

Abstract

Propolis is a natural resinous substance collected by honeybees from buds and exudates of trees. The material has attracted much attention in recent years as a functional food component since it possesses various biological properties, including antimicrobial, antioxidative, and anti-ulcer properties. In this study, the performance of accelerated solvent extraction (ASE) was assessed and compared with varying methods of extraction: soaking (maceration), ultrasonication, and microwave-assisted methods. Gas chromatography-mass spectrometry (GC-MS) and other spectroscopic techniques, such as absorbance and fluorescence, were employed to assess the efficiency in the extraction of natural products. The antioxidant activity and phenolic content of the different extracts were also determined. Results showed samples obtained from the microwave method showed the highest yield. Some issues and recommendations on the application of ASE for extracting natural products from bee propolis were discussed.
Co-Authors Alinsug, Malona V Charland, Jozlyn M Micor, Jose Rene L Mojica, Elmer-Rico E.