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All Journal Jurnal Ilmu Dasar JFA (Jurnal Fisika dan Aplikasinya)
Hariyanto, Aditya Prayugo
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Control & Systems Engineering Mathematics Physics

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Evaluation Treatment Planning for Breast Cancer Based on Dose-Response Model Aisyah, Siti; Hariyanto, Aditya Prayugo; Endarko, Endarko; Rubiyanto, Agus; Nasori, Nasori; Haekal, Mohammad; Nainggolan, Andreas
Jurnal ILMU DASAR Vol 22 No 1 (2021)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jid.v22i1.19732

Abstract

The delivery of radiation therapy to patients requires prior planning made by medical physicists to achieve radiotherapy goals. Radiotherapy has a plan to eradicate the growth of cancer cells by giving high doses and minimizing the radiation dose to normal tissue. Evaluation of planning is generally done based on dosimetric parameters, such as minimum dose, maximum dose, and means dose obtained from the DVHs data. Based on the same DVHs, data were evaluate dinterms of biological effects to determine the highest possible toxicity in normal tissue after the tumor had been treated with radiation using the NTCP model. The evaluation was conducted by selecting three DICOM-RT data of post-mastectomy right breast cancer patients who had been prescribed a dose of 50 Gy obtained from the Hospital MRCCC Siloam Semanggi database. All data were processed using open-source software DICOManTX to get the DVH and isodose information. Matlab-based CERR software was used to calculate the NTCP model. The results show that the three patients' DVH and isodose treatment planning result in a homogeneous dose distribution result because the PTV area obtains adose limit of ≥ 95%. Moreover, normalt issue still gets adose below the tolerance limit based on the standard from RTOG 1005 and ICRU 83. Analysis of NTCP shows a complication probability below 1% for each organ, suggesting that any organ which has been irradiated has a low likelihood of complications. Therefore, it can be concluded that the treatment planning which has been made in the three patients using the IMRT technique has achieved the objectives of radiotherapy, which is to minimize toxicity to healthy organs. |Keywords: DVH, isodose, NTCP, radiotherapy.
The Effect of Pattern and Infill Percentage in 3D Printer for Phantom Radiation Applications Hariyanto, Aditya Prayugo; Christianti, Kurnia Hastu; Rubiyanto, Agus; Nasori, Nasori; Haekal, Mohammad; Endarko, Endarko
Jurnal ILMU DASAR Vol 23 No 2 (2022)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jid.v23i2.27256

Abstract

3D printing technology was capable of fabricating phantoms to enhance quality assurance in radiation therapy. The ideal phantom has properties equivalent to the real tissue. However, 3D Printing has the limits to mimicking the attenuation properties of various tissues because during 3D printing there can be only one type of material. The purpose of this study was to evaluate the effect of infill percentage and infill patterns of 3D printing technology to simulate various types of tissue. This study used 25 samples measuring 5 × 5 × 1 cm3 from PETG material. The 20 samples were printed using variations infill percentages from 5 - 100% and the infill pattern in lines. The five samples were then printed with the infill percentage constant at 50% and used the infill pattern triangles, grid, gyroid, octet, and concentric. We used Computed Tomography (CT) to determine the Hounsfield Unit (HU) value for each sample and evaluated the suitability of each sample for phantom applications in radiation therapy and radiology. However, none of the samples was able to simulate compact bone. As a result, we found that PETG material could simulate the properties of soft tissue, fat, lung, kidney, liver, pancreas, and spongy bone. Thus, the study had shown promising potential for the fabrication of the anthropomorphic phantom of radiation therapy.
Assessment of 3D-Printed Bolus for Post-Mastectomy Breast Cancer Radiation Therapy Aini, Urifa Nabihal; Annisa, Hayfa; Maharani, Diska; Hariyanto, Aditya Prayugo; Rubiyanto, Agus; Nasori, Nasori; Mario, Aloysious; Endarko, Endarko
Jurnal Fisika dan Aplikasinya Vol 20, No 2 (2024)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat, LPPM-ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j24604682.v20i2.20671

Abstract

The fabricated 3D-printed bolus with 5 mm thick PLA and TPU materials was successfully used to analyze the air gap, relative electron density ( RED), and mass attenuation coefficient values for Post-Mastectomy Breast Cancer Radiation Therapy (PMRT). The 3D bolus was designed using 3D-Slicer Segment Editor software according to the thickness used, then smoothed and finished using Autodesk Meshmixer software, and printed on a 3D Creality printer. The air gap value was then analyzed by taking images from the phantom and 3D-printed bolus on a CT-Scan, then processed on Radiant DICOM, and the air gap value for the two 3D bolus materials was obtained. Analysis of two 3D bolus materials, PLA and TPU, showed that TPU is more suitable for bolus use in postmastectomy breast cancer cases based on its material properties. In addition, TPU is also better in terms of the air gap value because it has a smaller air gap, an RED value that is almost close to that of breast tissue, and better mass attenuation. Therefore, the recommended 3D-printed bolus material is TPU with a thickness of 5 mm as a tissue substitute for postmastectomy breast cancer cases.
Co-Authors Agus Rubiyanto Aini, Urifa Nabihal Annisa, Hayfa Christianti, Kurnia Hastu Endarko Endarko Haekal, Mohammad Maharani, Diska Mario, Aloysious Nainggolan, Andreas Nasori, Nasori Siti Aisyah