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Hubungan Nilai Rasio Neutrofil-Limfosit Pra Pembedahan dengan Prognosis Kanker Ovarium Jenis Epitelial di RSUP Dr. Sardjito Rifqi, Rifqi; Alkaff, Muhammad Lutfi; Pradjatmo, Heru
JURNAL KESEHATAN REPRODUKSI Vol 10, No 2 (2023)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.65530

Abstract

LATAR BELAKANG: Kanker ovarium merupakan salah satu keganasan pada perempuan yang paling sering dan mematikan. Angka kejadian kanker ovarium di Indonesia mencapai 15 per 100.000 dan menempati urutan kelima penyebab kematian terbanyak akibat kanker pada wanita di Indonesia. Lebih dari 75% pasien kanker ovarium terdiagnosis pada stadium lanjut. Setelah menjalani tatalaksana primer, 50% pasien akan mengalami rekurensi dalam waktu 1 tahun, dan angka 5 years survival rate kurang dari 50%. Secara umum, prognosis kanker ovarium epitelial secara independen dipengaruhi oleh stadium, tipe dan derajat histologis, serta diameter residu maksimum setelah operasi sitoreduktif. Rasio neutrofil-limfosit (RNL), suatu prediktor status inflamasi, telah terbukti menjadi penanda prognostik yang efektif untuk sebagian keganasan, termasuk keganasan ovarium. Nilai RNL yang tinggi menggambarkan kecenderungan peningkatan inflamasi pro-tumor dan penurunan kapasitas imun anti-tumor.TUJUAN: Mengetahui hubungan antara Rasio Neutrofil-Limfosit (RNL) pra pembedahan primer dengan prognosis kanker ovarium epitelial pada pasien kanker ovarium di RSUP Dr. Sardjito, Yogyakarta.METODE: Penelitian ini merupakan penelitian uji prognosis dengan rancangan kohort retrospektif yang melibatkan 106 penderita kanker ovarium di RSUP Sardjito yang memenuhi kriteria inklusi. Sumber data berasal dari data sekunder yang diambil dari Instalasi Catatan Medik (ICM) dalam kurun waktu Januari 2016 sampai dengan Maret 2019.HASIL: Dari 106 subjek, didapatkan rerata usia pasien adalah 48.58 dengan 69.8% subjek merupakan multipara. Sebanyak 50.94% subyek didapatkan dalam stadium lanjut (III dan IV) dan 71.7% merupakan tumor high grade. Risiko relatif subyek dengan RNL ≥ 3,1 yang mengalami Progression Free Survival (PFS) < 12 bulan adalah sebesar 9.896 (CI 95% = 1.646-101.413, p = 0.003). Analisis hubungan antara umur, indeks massa tubuh, paritas, kadar CA-125 pre operatif, stadium, dan tumor grade dengan RNL menunjukkan bahwa secara statistik maupun klinis hanya stadium yang memiliki hubungan yang bermakna dengan RNL (RR = 1.618, CI 95% = 1.179-2.220, p = 0.002). Analisis hubungan antara umur, indeks massa tubuh, paritas, kadar CA-125 pre operatif, stadium, dan tumor grade dengan PFS menunjukkan bahwa secara statistik maupun klinis hanya stadium yang memiliki hubungan yang bermakna dengan PFS (RR = 3.370, CI 95% = 1.187-9.573, p = 0. 012). Hasil analisis multivariat menunjukkan bahwa secara bersamaan RNL > 3.1 dan stadium lanjut berhubungan dengan PFS secara klinis maupun statistik. KESIMPULAN: RNL pra pembedahan > 3.1 berhubungan dengan kejadian PFS <12 bulan pada pasien kanker ovarium epitelial di RSUP Dr. Sardjito. Pasien kanker ovarium epitelial dengan RNL > 3.1 dan stadium lanjut mengalami PFS < 12 bulan.KATA KUNCI: Kanker ovarium epitelial, Rasio Neutrofil-Limfosit, progression free survival.
PENGARUH SUDUT ELEKTRODA 75, 85, 90 PADA LONGITUDINAL ARAH MUNDUR TERHADAP PRESENTASE PENETRASI Hafni, Hafni; Rifqi, Rifqi
Jurnal Teknologi dan Vokasi Vol 1 No 1 (2023): Jurnal Teknologi dan Vokasi
Publisher : ITP Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21063/jtv.2023.1.1.68-74

Abstract

Shielded Metal Arc Welding (SMAW) is one of the liquid welding processes (fusion welding) that produces a homogeneous fusion of the electrode with the base metal (base metal), which is caused by an electric arc that generates high heat to melt the electrode and base metal (base metal). simultaneously and protected by a shielding gas from the chemical reaction of the electrode flux. The depth of fusion formed is determined by the heat input, the electrode angle and the welding direction. The research was conducted at the Mechanical Engineering Laboratory of the Padang Institute of Technology. The base metal used is low carbon steel ST 37 with a thickness of 10 mm and a length of 100 mm. width 100mm. Welding is carried out on the surface of the base metal in the flat position, the type of connection (weld type) is a surfacing weld with 4 welding lines, each strip having a distance of 20 mm. Weld length 100mm. AWS E 6013 electrode specifications with a diameter of 3.2 mm. SMAW welding machine AC current with a voltage of 30 V. current 85 A. The measured electrode angle between the electrode and the welding line is 750, 850, 900. The backward welding direction where the electrode draws the welding fluid into the welding path and the normal arc height where the distance between the electrode and the base metal is equal to the diameter of the electrode. From the welding results, a penetration presentation will be obtained, namely the ratio of the depth of fusion to the width.  The research results obtained welding speed: 2.48 mm/s for electrode angle 750, 2.49 mm/s for electrode angle 850 and 2.51 mm/s for electrode angle 90. Heat input for electrode angle 750 is 1015.93 J/ mm, the heat input for the electrode angle 850 is 1024.20 J/mm and the heat input for the electrode angle 900 is 1015.93 J/mm. From the comparison of the width with the depth of fusion, it is obtained; The electrode angle 85 has a penetration presentation of 9.85%, which is better in height than the electrode angle 750, which has a penetration presentation of 8.43%, and the electrode angle 900 has a penetration presentation of 8.35%.
PENGARUH SUDUT ELEKTRODA 75, 85, 90 PADA LONGITUDINAL ARAH MUNDUR TERHADAP PRESENTASE PENETRASI Hafni, Hafni; Rifqi, Rifqi
Jurnal Teknologi dan Vokasi Vol 1 No 1 (2023): Jurnal Teknologi dan Vokasi
Publisher : ITP Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21063/jtv.2023.1.1.68-74

Abstract

Shielded Metal Arc Welding (SMAW) is one of the liquid welding processes (fusion welding) that produces a homogeneous fusion of the electrode with the base metal (base metal), which is caused by an electric arc that generates high heat to melt the electrode and base metal (base metal). simultaneously and protected by a shielding gas from the chemical reaction of the electrode flux. The depth of fusion formed is determined by the heat input, the electrode angle and the welding direction. The research was conducted at the Mechanical Engineering Laboratory of the Padang Institute of Technology. The base metal used is low carbon steel ST 37 with a thickness of 10 mm and a length of 100 mm. width 100mm. Welding is carried out on the surface of the base metal in the flat position, the type of connection (weld type) is a surfacing weld with 4 welding lines, each strip having a distance of 20 mm. Weld length 100mm. AWS E 6013 electrode specifications with a diameter of 3.2 mm. SMAW welding machine AC current with a voltage of 30 V. current 85 A. The measured electrode angle between the electrode and the welding line is 750, 850, 900. The backward welding direction where the electrode draws the welding fluid into the welding path and the normal arc height where the distance between the electrode and the base metal is equal to the diameter of the electrode. From the welding results, a penetration presentation will be obtained, namely the ratio of the depth of fusion to the width.  The research results obtained welding speed: 2.48 mm/s for electrode angle 750, 2.49 mm/s for electrode angle 850 and 2.51 mm/s for electrode angle 90. Heat input for electrode angle 750 is 1015.93 J/ mm, the heat input for the electrode angle 850 is 1024.20 J/mm and the heat input for the electrode angle 900 is 1015.93 J/mm. From the comparison of the width with the depth of fusion, it is obtained; The electrode angle 85 has a penetration presentation of 9.85%, which is better in height than the electrode angle 750, which has a penetration presentation of 8.43%, and the electrode angle 900 has a penetration presentation of 8.35%.
ANALISIS FAKTOR-FAKTOR YANG MEMENGARUHI PRODUKSI PADI SAWAH (ORYZA SATIVA L) TADAH HUJAN Rifqi, Rifqi; Sudrajat, Jajat; Oktoriana, Shenny
Jurnal Sains Pertanian Equator Vol 14, No 4: In Press
Publisher : Fakultas Pertanian Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/jspe.v14i4.91351

Abstract

Tujuan dari penelitian ini adalah untuk mengetahui faktor-faktor yang mempengaruhi produksi padi sawah tadah hujan. Metode analisis yang diterapkan menggunakan metode deskriptif kuantitatif. Data dianalisis menggunakan analisis regresi model Cobb Douglas untuk melihat pengaruh masing-masing faktor produksi terhadap produksi yang dihasilkan. Analisis kuantitatif menggunakan metode analisis regresi berganda. Berdasarkan hasil penelitian, faktor yang mempengaruhi produksi padi sawah tadah hujan adalah benih dan luas lahan.